2082752-83-6
Chemical Structure
Aclimostat
Synonym(s): ZGN-1061
- CAS No.: 2082752-83-6
- Formula:C26H42N2O6
- Molecular Weight:478.62
IUPAC Name: (3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl 3-(2-morpholinoethyl)azetidine-1-carboxylate
InChIKey: QJWJPMLDQYEPPW-AUKZVGPFSA-N
SMILES: C[C@]1([C@H](O1)C/C=C(C)\C)[C@]2([H])[C@]3(CC[C@H]([C@H]2OC)OC(N4CC(C4)CCN5CCOCC5)=O)CO3
Biological Activity: Aclimostat (ZGN-1061) is a potent inhibitor of the MetAP2 enzyme and displays favorable efficacy and safety in preclinical studies. ZGN-1061 produced similar efficacy as beloranib for weight loss, improvements in metabolic parameters in a mouse model of obesity and insulin resistance, and concordant changes in gene transcription in HepG2 cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aclimostat | 98.0% | Aclimostat (ZGN-1061) is a potent inhibitor of the MetAP2 enzyme and displays favorable efficacy and safety in preclinical studies. ZGN-1061 produced similar efficacy as beloranib for weight loss, improvements in metabolic parameters in a mouse model of obesity and insulin resistance, and concordant changes in gene transcription in HepG2 cells. | ||||||||||||||||||||
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Keywords
