2. Metabolic Enzyme/Protease
  3. MetAP
  4. LAF389

LAF389, a benaamide B analogue, is a methionine aminopeptidases (MetAps) inhibitor with an IC50 of 800 nM for MetAp2. LAF389 has both antiproliferative and antiangiogenetic properties and can inhibit tumor cells growth. LAF389 can be used for the research of cancer.

For research use only. We do not sell to patients.

LAF389

LAF389 Chemical Structure

CAS No. : 270902-51-7

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LAF389 Related Antibodies

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Description

LAF389, a benaamide B analogue, is a methionine aminopeptidases (MetAps) inhibitor with an IC50 of 800 nM for MetAp2. LAF389 has both antiproliferative and antiangiogenetic properties and can inhibit tumor cells growth. LAF389 can be used for the research of cancer[1][2].

IC50 & Target[1]

MetAp2

800 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
13 nM
Compound: LAF389
Antiproliferative activity against human A549 cells after 96 hrs
Antiproliferative activity against human A549 cells after 96 hrs
[PMID: 28185457]
HCT-116 IC50
23 nM
Compound: LAF389
Antiproliferative activity against human HCT116 cells after 96 hrs
Antiproliferative activity against human HCT116 cells after 96 hrs
[PMID: 28185457]
MDA-MB-435 IC50
40 nM
Compound: LAF389
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 28185457]
Molecular Weight

498.61

Formula

C25H42N2O8
CAS No.
SMILES

CC(C)(C)/C=C/[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC)C(N[C@H]1CC[C@H](CNC1=O)OC(C2CCCCC2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LAF389 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LAF389270902-51-7LAF 389LAF-389MetAPMethionine Aminopeptidasemethionine aminopeptidasesMetApsantiproliferativeantiangiogenetictumorcancerInhibitorinhibitorinhibit

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