369358-07-6
Chemical Structure
A-357300
- CAS No.: 369358-07-6
- Formula:C15H22ClN3O3S
- Molecular Weight:359.87
IUPAC Name: N'-((2S,3R)-3-amino-2-hydroxy-5-(isopropylthio)pentanoyl)-3-chlorobenzohydrazide
InChIKey: BYBVYIPUGPZRSX-OLZOCXBDSA-N
SMILES: CC(C)SCC[C@@H](N)[C@H](O)C(NNC(C1=CC(Cl)=CC=C1)=O)=O
Biological Activity: A-357300 is a reversible and selective MetAP2 inhibitor with IC50s of 0.12 and 57 μM against MetAP2 and MetAP1. A-357300 induces cytostasis by cell cycle arrest at the G1 phase selectively in endothelial cells and in a subset of tumor cells. A-357300 inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models. A-357300 can be used for the studies of neuroblastoma, fibrosarcoma and breast cancer[1].
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A-357300 | A-357300 is a reversible and selective MetAP2 inhibitor with IC50s of 0.12 and 57 μM against MetAP2 and MetAP1. A-357300 induces cytostasis by cell cycle arrest at the G1 phase selectively in endothelial cells and in a subset of tumor cells. A-357300 inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models. A-357300 can be used for the studies of neuroblastoma, fibrosarcoma and breast cancer. | |||||||||||||||||||||
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