2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Elamipretide TFA

Elamipretide TFA  (Synonyms: MTP-131 TFA; RX-31 TFA; SS-31 TFA)

Cat. No.: HY-P0125A
Handling Instructions

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Elamipretide TFA (MTP-131 TFA; RX-31 TFA; SS-31 TFA) is the TFA salt form of Elamipretide (HY-P0125). Elamipretide TFA is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Elamipretide TFA Chemical Structure

Elamipretide TFA Chemical Structure

CAS No. : 1606994-55-1

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Other Forms of Elamipretide TFA:

Elamipretide TFA Related Antibodies

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Description

Elamipretide TFA (MTP-131 TFA; RX-31 TFA; SS-31 TFA) is the TFA salt form of Elamipretide (HY-P0125). Elamipretide TFA is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury[1][2].

IC50 & Target

Cardiolipin peroxidase[1]
In Vivo

Elamipretide TFA (5 mg/kg, i.p., once daily for 3 days) exhibits neuroprotective effects, protects the hippocampus from mitochondrial dysfunction, and attenuates the oxidative stress and inflammatory response in Lipopolysaccharide (HY-D1056)-induced cognitive impairment in C57BL/6 mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced cognitive impairment in C57BL/6 mice model[1]
Dosage: 5 mg/kg
Administration: i.p., once daily for 3 days
Result: Maintained the mitochondrial function, ROS and MDA levels, and SOD activity.
Inhibited neural cell apoptosis in hippocampus, enhanced the hippocampal BDNF pathway and synaptic structural complexity.
Molecular Weight

753.81

Formula

C34H50F3N9O7
CAS No.
Appearance

Solid

Sequence

{d-Arg}-{Dmt}-Lys-Phe-NH2
Sequence Shortening

{d-Arg}-{Dmt}-KF-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (66.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3266 mL 6.6330 mL 13.2659 mL
5 mM 0.2653 mL 1.3266 mL 2.6532 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3266 mL 6.6330 mL 13.2659 mL 33.1649 mL
5 mM 0.2653 mL 1.3266 mL 2.6532 mL 6.6330 mL
10 mM 0.1327 mL 0.6633 mL 1.3266 mL 3.3165 mL
15 mM 0.0884 mL 0.4422 mL 0.8844 mL 2.2110 mL
20 mM 0.0663 mL 0.3316 mL 0.6633 mL 1.6582 mL
25 mM 0.0531 mL 0.2653 mL 0.5306 mL 1.3266 mL
30 mM 0.0442 mL 0.2211 mL 0.4422 mL 1.1055 mL
40 mM 0.0332 mL 0.1658 mL 0.3316 mL 0.8291 mL
50 mM 0.0265 mL 0.1327 mL 0.2653 mL 0.6633 mL
60 mM 0.0221 mL 0.1105 mL 0.2211 mL 0.5527 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Elamipretide TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elamipretide1606994-55-1MTP-131RX-31SS-31MTP131MTP 131RX31RX 31SS31SS 31Mitochondrial Metabolismheart failureC57BL/6 miceAlzheimer’s diseaseParkinson’s disease,Inhibitorinhibitorinhibit

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