2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Elamipretide

Elamipretide  (Synonyms: MTP-131; RX-31; SS-31)

Cat. No.: HY-P0125
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Elamipretide (MTP-131) is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Elamipretide Chemical Structure

Elamipretide Chemical Structure

CAS No. : 736992-21-5

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Other Forms of Elamipretide:

Elamipretide Related Antibodies

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Description

Elamipretide (MTP-131) is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury[1][2].

IC50 & Target

Cardiolipin peroxidase[1]
In Vivo

Elamipretide (5 mg/kg, i.p., once daily for 3 days) exhibits neuroprotective effects, protects the hippocampus from mitochondrial dysfunction, and attenuates the oxidative stress and inflammatory response in Lipopolysaccharide (HY-D1056)-induced cognitive impairment in C57BL/6 mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced cognitive impairment in C57BL/6 mice model[1]
Dosage: 5 mg/kg
Administration: i.p., once daily for 3 days
Result: Maintained the mitochondrial function, ROS and MDA levels, and SOD activity.
Inhibited neural cell apoptosis in hippocampus, enhanced the hippocampal BDNF pathway and synaptic structural complexity.
Molecular Weight

639.79

Formula

C32H49N9O5
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{d-Arg}-{Dmt}-Lys-Phe-NH2
Sequence Shortening

{d-Arg}-{Dmt}-KF-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 29 mg/mL (45.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5630 mL 7.8151 mL 15.6301 mL
5 mM 0.3126 mL 1.5630 mL 3.1260 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5630 mL 7.8151 mL 15.6301 mL 39.0753 mL
5 mM 0.3126 mL 1.5630 mL 3.1260 mL 7.8151 mL
10 mM 0.1563 mL 0.7815 mL 1.5630 mL 3.9075 mL
15 mM 0.1042 mL 0.5210 mL 1.0420 mL 2.6050 mL
20 mM 0.0782 mL 0.3908 mL 0.7815 mL 1.9538 mL
25 mM 0.0625 mL 0.3126 mL 0.6252 mL 1.5630 mL
30 mM 0.0521 mL 0.2605 mL 0.5210 mL 1.3025 mL
40 mM 0.0391 mL 0.1954 mL 0.3908 mL 0.9769 mL
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Elamipretide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elamipretide736992-21-5MTP-131 RX-31 SS-31MTP131MTP 131RX31RX 31RX-31SS31SS 31SS-31Mitochondrial Metabolismmitochondriaheart failurecardiovascular diseasescardiolipinmyocardial energeticsInhibitorinhibitorinhibit

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