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  4. Anti-inflammatory agent 49

nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM.

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Anti-inflammatory agent 49 Chemical Structure

Anti-inflammatory agent 49 Chemical Structure

CAS No. : 851471-44-8

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Anti-inflammatory agent 49 Related Antibodies

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Description

nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM[1].

IC50 & Target

IC50: 270 nM (dynamin-related protein 1 ,Drp1 )[1]
In Vitro

1.Anti-inflammatory agent 49 can reduce the mitochondrial dysfunction of H9c2 cells induced by LPS (HY-D1056) and save the mice endotoxemia induced by LPS[1].
2.Anti-inflammatory agent 49 inhibits Drp1 association with the mitochondria and Drp1-Fis1 interaction following LPS treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 49 Related Antibodies

Cell Viability Assay

Cell Line: H9c2 cells[1]
Concentration: 2 µM
Incubation Time: 16 h
Result: Decreased the percentage of cells with fragmented mitochondria. The percent of fragmented cells was decreased from 22% (LPS + Veh) to 9% (LPS + SC9), relative to 4% in the absence of LPS[1].

Western Blot Analysis

Cell Line: H9c2 cells[1]
Concentration: 2 µM
Incubation Time: 24 h
Result: Decreased the number of high Drp1-Fis1 cells from 67% (LPS + Veh) to 28% (LPS + P110) and to 14% (LPS + SC9).[1]
In Vivo

Anti-inflammatory agent 49 (10 mg/kg, every 8 h for 72 h) rescues mice from LPS-induced endotoxemia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c AnNCrl micee (Strain Code 028)[1]
Dosage: LPS doses 10–16.67 mg/kg, SC9 doses 10 mg/kg(after 4 h)
Administration: Intraperitoneal injection: 0.2 mL of LPS,0.1 mL of CS9; scored every 8 h for 72 h.
Result: Improved mouse survival at all LPS doses tested at the different LPS doses (10 to 16.6 mg/kg) .
Dramatically reduced the occurrence of critical symptoms such as respiratory distress.
Molecular Weight

466.52

Formula

C21H22N8O3S
CAS No.
SMILES

O=C1NC(N(CC2=CC=CC=C2)C(N)=C1N(C)C(CSC3=NN4C(C)=CC(C)=NC4=N3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 49 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 49851471-44-8OthersDrp1-Fis1 inhibtorInhibitorinhibitorinhibit

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Anti-inflammatory agent 49
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