1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Clobetasone butyrate

Clobetasone butyrate 

Cat. No.: HY-B1616 Purity: 99.77%
Handling Instructions

Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis.

For research use only. We do not sell to patients.

Clobetasone butyrate Chemical Structure

Clobetasone butyrate Chemical Structure

CAS No. : 25122-57-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 105 In-stock
Estimated Time of Arrival: December 31
100 mg USD 95 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis[1].

IC50 & Target

IC50: glucocorticoid[1]

In Vivo

Clobetasone butyrate (application on the skin; 0.05%; 7 weeks) induces epidermal thinning in skin, Clobetasone butyrate 7 weeks causes much less epidermal thinning in the pig than flurandrenolone (0.05%) or fluocinolone acetonide (0.025%), both of which causes severe atrophy[1].

Animal Model: Large white domestic pig[1]
Dosage: 0.5% application on the skin
Administration: 7 weeks
Result: Caused moderate to slight atrophy.
Molecular Weight

478.98

Formula

C₂₆H₃₂ClFO₅

CAS No.

25122-57-0

SMILES

C[[email protected]@]1(C2)[[email protected]](C(CCl)=O)(OC(CCC)=O)[[email protected]@H](C)C[[email protected]@]1([H])[[email protected]]3([H])CCC4=CC(C=C[[email protected]]4(C)[[email protected]@]3(F)C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (521.94 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0878 mL 10.4388 mL 20.8777 mL
5 mM 0.4176 mL 2.0878 mL 4.1755 mL
10 mM 0.2088 mL 1.0439 mL 2.0878 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (13.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Clobetasone butyrateGlucocorticoid ReceptorTrimovateatopicADdermatitispsoriasiseczemacorticosteroidinflammatoryskinInhibitorinhibitorinhibit

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Product Name:
Clobetasone butyrate
Cat. No.:
HY-B1616
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