1. Immunology/Inflammation
  2. NO Synthase
  3. NOS-IN-2

NOS-IN-2 (Compound 4i) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 20 µM, without inhibiting eNOS. NOS-IN-2 has little toxicity and can be used for studying inflammatory disorders.

For research use only. We do not sell to patients.

NOS-IN-2 Chemical Structure

NOS-IN-2 Chemical Structure

CAS No. : 2766146-79-4

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Description

NOS-IN-2 (Compound 4i) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 20 µM, without inhibiting eNOS. NOS-IN-2 has little toxicity and can be used for studying inflammatory disorders[1].

IC50 & Target

iNOS

20 μM (IC50)

nNOS

>1000 μM (IC50)

In Vitro

NOS-IN-2 (Compound 4i) shows high iNOS selectivity without eNOS inhibition activity [1].
NOS-IN-2 (0-100 µM, 30 min) has little toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HUVECs
Concentration: 10, 20, 50, 100, 500 µM
Incubation Time: 30 min
Result: Had little toxicity, only at the concentration above 100 µM, the cell viability was significantly (approximately 20%) reduced.
In Vivo

NOS-IN-2 (Compound 4i) is predicted to show oral bioavailability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

367.37

Formula

C18H20F3N3O2

CAS No.
SMILES

COC1=CC=C(C(C(CCNC(C2=CC=C(C=C2)C(F)(F)F)=N)O)=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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NOS-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NOS-IN-2
Cat. No.:
HY-115916
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