1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. PS372424 hydrochloride

PS372424 hydrochloride 

Cat. No.: HY-111149A
Handling Instructions

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity.

For research use only. We do not sell to patients.

PS372424 hydrochloride Chemical Structure

PS372424 hydrochloride Chemical Structure

CAS No. : 1596362-29-6

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5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity[1][2].

In Vitro

PS372424 (100 ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5 min of stimulation[1].
PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells[2].

Western Blot Analysis[2]

Cell Line: CXCR3+ T cells and CXCR3- T cells
Concentration: 10, 50, 100, or 200 nM
Incubation Time: 30 minutes
Result: Caused a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells. Did not result in phosphorylation of CCR5 on CXCR3- T cells.
Molecular Weight

625.20

Formula

C₃₃H₄₅ClN₆O₄

CAS No.

1596362-29-6

SMILES

O=C([[email protected]]1N(C(CCC(C2=CC=CC=C2)=O)=O)CC3=C(C=CC=C3)C1)N[[email protected]](C(NCC4CCCCC4)=O)CCCNC(N)=N.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

PS372424PS 372424PS-372424CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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Product Name:
PS372424 hydrochloride
Cat. No.:
HY-111149A
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