1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. PS372424

PS372424 

Cat. No.: HY-111149
Handling Instructions

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM.

For research use only. We do not sell to patients.

PS372424 Chemical Structure

PS372424 Chemical Structure

CAS No. : 914291-61-5

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Description

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM[1][2][3].

IC50 & Target[1]

CXCR3

 

In Vitro

PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells[1].

Western Blot Analysis[1]

Cell Line: CXCR3+ T cells and CXCR3- T cells
Concentration: 10, 50, 100, or 200 nM
Incubation Time: 30 minutes
Result: Caused a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells. Did not result in phosphorylation of CCR5 on CXCR3- T cells.
Molecular Weight

588.74

Formula

C₃₃H₄₄N₆O₄

CAS No.

914291-61-5

SMILES

O=C([[email protected]]1N(C(CCC(C2=CC=CC=C2)=O)=O)CC3=C(C=CC=C3)C1)N[[email protected]](C(NCC4CCCCC4)=O)CCCNC(N)=N

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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