1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. PS372424

PS372424 

Cat. No.: HY-111149
Handling Instructions

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity.

For research use only. We do not sell to patients.

PS372424 Chemical Structure

PS372424 Chemical Structure

CAS No. : 914291-61-5

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Description

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity[1][2].

IC50 & Target[1]

CXCR3

 

In Vitro

PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells[1].

Western Blot Analysis[1]

Cell Line: CXCR3+ T cells and CXCR3- T cells
Concentration: 10, 50, 100, or 200 nM
Incubation Time: 30 minutes
Result: Caused a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells. Did not result in phosphorylation of CCR5 on CXCR3- T cells.
Molecular Weight

588.74

Formula

C₃₃H₄₄N₆O₄

CAS No.

914291-61-5

SMILES

O=C([[email protected]]1N(C(CCC(C2=CC=CC=C2)=O)=O)CC3=C(C=CC=C3)C1)N[[email protected]](C(NCC4CCCCC4)=O)CCCNC(N)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

PS372424PS 372424PS-372424CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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