1. Metabolic Enzyme/Protease
    Immunology/Inflammation
  2. Phospholipase
    COX
  3. Alminoprofen

Alminoprofen (Synonyms: EB-382)

Cat. No.: HY-17485 Purity: 99.35%
Handling Instructions

Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen possesses both antiphospholipase A2 (PLA2) activity and anti-cycloxygenase (COX) activity.

For research use only. We do not sell to patients.

Alminoprofen Chemical Structure

Alminoprofen Chemical Structure

CAS No. : 39718-89-3

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Description

Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen possesses both antiphospholipase A2 (PLA2) activity and anti-cycloxygenase (COX) activity[1].

IC50 & Target[1]

sPLA2

 

COX-2

 

In Vitro

Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both sPLA2 but also COX-2. Alminoprofen (from 0 to 50 μM) induces a dose-related inhibitory response on thelevels of PGE2 formed by the CRL-1517 cell line[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Alminoprofen (100-300 mg/kg) exerts an anti-inflammatory activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Groups of Wistar Rats (Oedema of the paw)[1]
Dosage: 100 mg/kg
Administration: P.o.
Result: Exerted a statistically significant dose-dependent antagonist action lasting throughout the 2-hr observation period.
Molecular Weight

219.28

Formula

C₁₃H₁₇NO₂

CAS No.

39718-89-3

SMILES

O=C(O)C(C)C1=CC=C(NCC(C)=C)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Keywords:

AlminoprofenEB-382EB382EB 382PhospholipaseCOXCyclooxygenaseNSAIDinflammationanalgesicphospholipiInhibitorinhibitorinhibit

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Alminoprofen
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