2. Apoptosis
  3. TNF Receptor
  4. Deoxyartemisinin

Deoxyartemisinin  (Synonyms: 2-Deoxyartemisinin)

Cat. No.: HY-W013331 Purity: 99.9%
COA
SDS
Handling Instructions Technical Support

Deoxyartemisinin (2-Deoxyartemisinin) is an orally active anti-inflammatory and analgesic agent. Deoxyartemisinin selectively reduces the level of the pro-inflammatory cytokine TNF-α. Deoxyartemisinin alleviates neuropathic pain, inflammatory pain, and croton oil-induced ear edema.\nDeoxyartemisinin exerts an analgesic effect against thermal stimulation. Deoxyartemisinin has anti-ulcer activity. Deoxyartemisinin can be used in research related to inflammatory diseases, pain, and gastric ulcers.

For research use only. We do not sell to patients.

Deoxyartemisinin

Deoxyartemisinin Chemical Structure

CAS No. : 72826-63-2

Size Price Stock Quantity
1 mg In-stock
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Deoxyartemisinin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Deoxyartemisinin

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Deoxyartemisinin (2-Deoxyartemisinin) is an orally active anti-inflammatory and analgesic agent. Deoxyartemisinin selectively reduces the level of the pro-inflammatory cytokine TNF-α. Deoxyartemisinin alleviates neuropathic pain, inflammatory pain, and croton oil-induced ear edema.\nDeoxyartemisinin exerts an analgesic effect against thermal stimulation. Deoxyartemisinin has anti-ulcer activity. Deoxyartemisinin can be used in research related to inflammatory diseases, pain, and gastric ulcers[1][2].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
> 50 μM
Compound: DART
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by Cell-titer Glo luminescent assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by Cell-titer Glo luminescent assay
[PMID: 38287228]
HUVEC IC50
> 50 μM
Compound: 12
Inhibitory activity against human umbilical vein endothelial cells (HUVEC) was assayed using MTT colorimetric proliferation assay
Inhibitory activity against human umbilical vein endothelial cells (HUVEC) was assayed using MTT colorimetric proliferation assay
[PMID: 14552753]
Parmacokinetics
Species Dose Route T1/2 Tmax Cmax AUClast AUCinf MRTlast C0 Vz CL
Rat[2] 5 mg/kg i.v. 1.45 h / / 219 ng·h/mL 222 ng·h/mL 0.671 h 1069 ng/mL 48.3 L/kg 385 mL/min/kg
Rat[2] 100 mg/kg p.o. 1.12 h 0.389 h 62.4 ng/mL 67.3 ng·h/mL 71.0 ng·h/mL 1.21 h / / /
In Vivo

Deoxyartemisinin (10-300 mg/kg; i.p.; single administration) reduces formaldehyde-induced neuropathic pain by 56.55% and inflammatory pain by 45.43% in male Swiss mice, exerts dose-dependent analgesic effects in the tail-flick test, and impairs spontaneous activity and motor coordination in male Swiss mice at the dose of 300 mg/kg[1].
Deoxyartemisinin (100 mg/kg; i.p.; single administration) reduces croton oil-induced ear swelling by 33.64% and selectively decreases TNF-α levels by 37.37% in male Swiss mice[1].
Deoxyartemisinin (50-200 mg/kg; p.o.; single administration) dose-dependently reduces the gastric ulcer injury index in ethanol-induced male Wistar rats, with an ED50 of 87.5 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice (male, 25-35 g)[1]
Dosage: 10 mg/kg; 30 mg/kg; 100 mg/kg
Administration: i.p.; single dose
Result: Reduced neurogenic pain by 0% and inflammatory pain by 1.69% (10 mg/kg).
Reduced neurogenic pain by 9.26% and inflammatory pain by 0% (30 mg/kg).
Reduced neurogenic pain by 56.55% and inflammatory pain by 45.43% (100 mg/kg).
Exerted a dose-dependent antinociceptive effect in the tail flick test
Animal Model: Swiss mice (male, 25-35 g)[1]
Dosage: 100 mg/kg
Administration: i.p.; single dose
Result: Reduced croton oil-induced ear edema by 33.64% compared to vehicle group.
Selectively reduced tumor necrosis factor alpha (TNF-α) levels by 37.37%, with no significant reduction in interleukin-1beta (IL-1β) or interleukin-6 (IL-6) levels.
Animal Model: Wistar rats (male, 200-300 g)[1]
Dosage: 50 mg/kg; 100 mg/kg; 200 mg/kg
Administration: p.o.; single dose
Result: Reduced ulcerative lesion index by 49.7% (50 mg/kg).
Reduced ulcerative lesion index by 74% (100 mg/kg).
Reduced ulcerative lesion index by 76.5% (200 mg/kg).
Had an effective dose 50 (ED50) of 87.5 mg/kg.
Molecular Weight

266.33

Formula

C15H22O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]1[C@@](CC[C@H]2C)([H])[C@@]([C@@]2([H])CC3)(O4)[C@@](OC1=O)([H])O[C@@]34C
Initial Source

Nocardia cwallina
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Deoxyartemisinin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deoxyartemisinin72826-63-22-DeoxyartemisininTNF ReceptorTumor Necrosis Factor ReceptorTNFRanti-inflammatory and analgesic agentSwiss miceWistar ratsGastric ulcerationpaininflammatory diseasesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Deoxyartemisinin
Cat. No.:
HY-W013331
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.