Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells

  • Bioorg Med Chem Lett. 2003 Nov 3;13(21):3665-8. doi: 10.1016/j.bmcl.2003.08.023.
Sangtae Oh  1 ,  In Howa Jeong ,  Woon-Seob Shin ,  Seokjoon Lee
Affiliations
  • 1. Department of Chemistry, Yonsei University, Wonju 220-710, South Korea.
PMID: 14552753 DOI: 10.1016/j.bmcl.2003.08.023
Abstract

Thioacetal artemisinin derivatives, in particular, 10alpha-phenylthiodihydroartemisinins (5), 10beta-benzenesulfonyl-9-epi-dihydroartemisinin (9) and 10alpha-mercaptodihydroartemisinin (11), exhibit good growth inhibition activity against HUVEC proliferation at the concentration level of 1 microM.