72826-63-2
Chemical Structure
Deoxyartemisinin
Synonym(s): 2-Deoxyartemisinin
- CAS No.: 72826-63-2
- Formula:C15H22O4
- Molecular Weight:266.33
IUPAC Name: (3R,3aS,3a1R,6R,6aS,9S,10aS)-3,6,9-trimethyloctahydro-10aH-3a1,9-epoxyoxepino[4,3,2-ij]isochromen-2(3H)-one
InChIKey: ZQGMLVQZBIKKMP-NNWCWBAJSA-N
SMILES: C[C@@H]1[C@@](CC[C@H]2C)([H])[C@@]([C@@]2([H])CC3)(O4)[C@@](OC1=O)([H])O[C@@]34C
Biological Activity: Deoxyartemisinin (2-Deoxyartemisinin) is an orally active anti-inflammatory and analgesic agent. Deoxyartemisinin selectively reduces the level of the pro-inflammatory cytokine TNF-α. Deoxyartemisinin alleviates neuropathic pain, inflammatory pain, and croton oil-induced ear edema.\nDeoxyartemisinin exerts an analgesic effect against thermal stimulation. Deoxyartemisinin has anti-ulcer activity. Deoxyartemisinin can be used in research related to inflammatory diseases, pain, and gastric ulcers[1][2].
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Deoxyartemisinin | 98.76% | Deoxyartemisinin (2-Deoxyartemisinin) is an orally active anti-inflammatory and analgesic agent. Deoxyartemisinin selectively reduces the level of the pro-inflammatory cytokine TNF-α. Deoxyartemisinin alleviates neuropathic pain, inflammatory pain, and croton oil-induced ear edema.\nDeoxyartemisinin exerts an analgesic effect against thermal stimulation. Deoxyartemisinin has anti-ulcer activity. Deoxyartemisinin can be used in research related to inflammatory diseases, pain, and gastric ulcers. | ||||||||||||||||||||
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- [1]. Favero FF, et al. Artemisinin and deoxyartemisinin isolated from Artemisia annua L. promote distinct antinociceptive and anti-inflammatory effects in an animal model. Biomed Pharmacother. 2024;178:117299. [Content Brief]
- [2]. Fu C, et al. Oral Bioavailability Comparison of Artemisinin, Deoxyartemisinin, and 10-Deoxoartemisinin Based on Computer Simulations and Pharmacokinetics in Rats. ACS Omega. 2020;6(1):889-899. Published 2020 Dec 28. [Content Brief]
Keywords
