2. Immunology/Inflammation
  3. COX
  4. Ketoprofen (lysinate)

Ketoprofen (lysinate)  (Synonyms: RP-19583 (lysinate))

Cat. No.: HY-B0227A
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Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity.

For research use only. We do not sell to patients.

CAS No. : 57469-78-0

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Ketoprofen (lysinate) Related Antibodies

Top Publications Citing Use of Products

    Ketoprofen (lysinate) purchased from MedChemExpress. Usage Cited in: Eur J Pharm Sci. 2023 Oct 1:189:106550.  [Abstract]

    Binding constants for ENC and BINI to HSA derived from fluorescence quenching data obtained at 25 °C in the absence and presence of IND, Ketoprofen, HEM.

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    COX COX-1 COX-2 COX-3

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    Description

    Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].

    IC50 & Target

    COX-1

    2 nM (IC50)

    COX-2

    26 nM (IC50)

    In Vitro

    Ketoprofen lysinate inhibits COX in LPS-stimulated monocytes isolated from human blood, with IC50 values of 2 nM (COX-1) and 26 nM (COX-2)[1].
    Ketoprofen lysinate (2.5 mg /mL, 3-24h) decreases the mRNA level of immune factors (TNFα, IL-8, SAA and COX-2) and PTGES in LPS-stimulated bovine mammary epithelial cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ketoprofen (lysinate) Related Antibodies

    RT-PCR[3]

    Cell Line: LPS (0.2 μg/mL)-stimulated bovine mammary epithelial cells
    Concentration: 2.5 mg /mL
    Incubation Time: 3, 6, 24 h
    Result: Decreased the mRNA level of TNFα, IL-8, SAA, COX-2 and PTGES.
    In Vivo

    Ketoprofen lysinate (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%)[2].
    Ketoprofen lysinate (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: HFD-induced obese C57BL/6 mice[2]
    Dosage: 10 mg/kg
    Administration: Oral administration, three times a week for 10 weeks
    Result: Decreased in relative body weight, the iWAT mass, and the level of leptin and resistin.
    Animal Model: LPS (0.2 μg/mL)-treated dairy cows [3]
    Dosage: 50 mg/kg
    Administration: Injection (Milk samples were taken every 30 min until 6 and 9 h)
    Result: Lowered the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk.
    Clinical Trial
    Molecular Weight

    400.47

    Formula

    C22H28N2O5
    CAS No.
    SMILES

    N[C@@H](CCCCN)C(O)=O.O=C(O)C(C)C1=CC=CC(C(C2=CC=CC=C2)=O)=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Ketoprofen (lysinate) Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ketoprofen (lysinate)57469-78-0RP-19583 (lysinate)COXCyclooxygenaseAnti-inflammatory agentsCOX inhibitorobesityHFD-induced obese mice3T3-L1 cellwhite adipocytesInhibitorinhibitorinhibit

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