Neutrophil elastase inhibitor 5
Based on 1 Customer Validation
Neutrophil elastase inhibitor 5 is an inhibitor of human neutrophil elastase (HNE), proteinase 3 (PR3) and sirt2, with IC50 values of 4.91, 20.69 and 2.42 μM, respectively. Neutrophil elastase inhibitor 5 inhibits superoxide anion production and elastase release in human neutrophils. Neutrophil elastase inhibitor 5 can be used for the research of neutrophil inflammatory diseases.
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- Pureza: 95.74%
- No. CAS: 3020696-44-7
- Fòrmula: C24H18N4O4
- Peso molecular:426.42
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
IC50: 4.91 μM (HNE); 20.69 μM (PR3)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Neutrophil | IC50 |
0.9 μM
Compound: 29
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Inhibition of O2 generation in fMLP/CB-induced human neutrophils by cell based assay
Inhibition of O2 generation in fMLP/CB-induced human neutrophils by cell based assay
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[PMID: 37939864] |
| Neutrophil | IC50 |
1.86 μM
Compound: 29
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Inhibition of elastase release in fMLP/CB-induced human neutrophils by cell based assay
Inhibition of elastase release in fMLP/CB-induced human neutrophils by cell based assay
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[PMID: 37939864] |
Neutrophil elastase inhibitor 5 (Compound 29) inhibits fMLF/CB-induced superoxide anion generation in human neutrophils with an IC50 of 0.90 µM[1].
Neutrophil elastase inhibitor 5 inhibits fMLF/CB-induced elastase release in human neutrophils with an IC50 of 1.86 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3020696-44-7
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Appearance Solid
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Peso molecular 426.42
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Fòrmula C24H18N4O4
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Color Orange to red
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SMILES
OC([C@H](C1=CC=CC=C1)NC(C2=NC=CC=C2/N=N/C3=C(C=CC=C4)C4=CC=C3O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 12.5 mg/mL (29.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
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- Español - ES (251 KB)
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- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3451 mL | 11.7255 mL | 23.4511 mL | 58.6276 mL |
| 5 mM | 0.4690 mL | 2.3451 mL | 4.6902 mL | 11.7255 mL | |
| 10 mM | 0.2345 mL | 1.1726 mL | 2.3451 mL | 5.8628 mL | |
| 15 mM | 0.1563 mL | 0.7817 mL | 1.5634 mL | 3.9085 mL | |
| 20 mM | 0.1173 mL | 0.5863 mL | 1.1726 mL | 2.9314 mL | |
| 25 mM | 0.0938 mL | 0.4690 mL | 0.9380 mL | 2.3451 mL |
Neutrophil elastase inhibitor 5 Related Classifications
HY-155414 Related Classifications
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- Neutrophil elastase inhibitor 5
- 3020696-44-7
- Neutrophil elastase inhibitor5
- Neutrophil elastase inhibitor-5
- Elastase
- Ser/Thr Protease
- Sirtuin
- superoxide anion generation
- cathepsin G
- human neutrophil elastase
- sirtuin 2
- human neutrophils
- fMLF/CB
- neutrophilic inflammatory diseases
- elastase release
- proteinase 3
- Inhibitor
- inhibitor
- inhibit