2. Metabolic Enzyme/Protease
  3. MMP
  4. cyclo(RLsKDK) TFA

cyclo(RLsKDK) TFA  (Synonyms: BK-1361 TFA)

Cat. No.: HY-P1676A Purity: 99.09%
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cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) (TFA) has potential applications in inflammatory diseases and cancer.

For research use only. We do not sell to patients.

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cyclo(RLsKDK) TFA Chemical Structure

cyclo(RLsKDK) TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 110 In-stock
5 mg USD 340 In-stock
10 mg USD 545 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of cyclo(RLsKDK) TFA:

cyclo(RLsKDK) TFA Related Antibodies

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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  • Purity & Documentation

  • References

  • Customer Review

Description

cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) (TFA) has potential applications in inflammatory diseases and cancer[1].

In Vitro

cyclo(RLsKDK) (TFA) promotes ADAM8 activation and CD23 shedding with IC50 values of 120 nM and 182 nM, respectively[2].
cyclo(RLsKDK) (TFA) (200 nM; 0-120 h) increases activity of pro-ADAM8[2].
cyclo(RLsKDK) (TFA) (200 nM and 500 nM; 12 h) promotes the growth of Panc1_ctrl and Panc1_A8 cells[2].
cyclo(RLsKDK) (TFA) (500 nM) causes ERK1/2 phosphorylation in Panc1_ctrl and Panc1_A8 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cyclo(RLsKDK) TFA Related Antibodies

Cell Invasion Assay[2]

Cell Line: Panc1_A8 cells.
Concentration: 10, 100 and 1,000 nM.
Incubation Time: 6 h.
Result: Reduced cell invasion with dose-dependent manner.
In Vivo

cyclo(RLsKDK) (TFA) (10 µg/g; i.p.; once weekly for 4 weeks) significantly reduces tumour load in mice which implant Panc1_ctrl or Panc1_A8 cells. cyclo(RLsKDK) (TFA) improves the survival rate of pancreatic ductal adenocarcinoma (PDAC) mice, reduces soluble ADAM8 (sADAM8) content, pERK1/2 activation, and PDAC metastasis in the liver and lungs of PDAC mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

841.88

Formula

C33H58F3N11O11
Appearance

Solid

Color

White to off-white

Sequence

Cyclo(Arg-Leu-{d-Ser}-Lys-Asp-Lys)
Sequence Shortening

Cyclo(RL-{d-Ser}-KDK)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (118.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1878 mL 5.9391 mL 11.8782 mL
5 mM 0.2376 mL 1.1878 mL 2.3756 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.09%

COA (248 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1878 mL 5.9391 mL 11.8782 mL 29.6954 mL
5 mM 0.2376 mL 1.1878 mL 2.3756 mL 5.9391 mL
10 mM 0.1188 mL 0.5939 mL 1.1878 mL 2.9695 mL
15 mM 0.0792 mL 0.3959 mL 0.7919 mL 1.9797 mL
20 mM 0.0594 mL 0.2970 mL 0.5939 mL 1.4848 mL
25 mM 0.0475 mL 0.2376 mL 0.4751 mL 1.1878 mL
30 mM 0.0396 mL 0.1980 mL 0.3959 mL 0.9898 mL
40 mM 0.0297 mL 0.1485 mL 0.2970 mL 0.7424 mL
50 mM 0.0238 mL 0.1188 mL 0.2376 mL 0.5939 mL
60 mM 0.0198 mL 0.0990 mL 0.1980 mL 0.4949 mL
80 mM 0.0148 mL 0.0742 mL 0.1485 mL 0.3712 mL
100 mM 0.0119 mL 0.0594 mL 0.1188 mL 0.2970 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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cyclo(RLsKDK) TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cyclo(RLsKDK)BK-1361BK1361BK 1361MMPMatrix metalloproteinasesPancreatic ductal adenocarcinomaPDACPDAC micePanc1_ctrl cellsPanc1_A8 cellsADAM8ERK1/2Inhibitorinhibitorinhibit

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