1. Metabolic Enzyme/Protease
  2. Tyrosinase
  3. Arbutin

Arbutin (Synonyms: β-Arbutin)

Cat. No.: HY-N0192 Purity: ≥98.0%
Handling Instructions

Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.

For research use only. We do not sell to patients.

Arbutin Chemical Structure

Arbutin Chemical Structure

CAS No. : 497-76-7

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10 g USD 108 In-stock
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Description

Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

IC50 & Target

Tyrosinase[1]

In Vitro

Arbutin (0.3-5.4 mM; 24 hours, 48 hours, 72 hours; B16 murine melanoma cells) inhibites the viability of B16 murine melanoma cells in a time-and dose-dependent manner[2].
Arbutin (1.4-5.4 mM; 24 hours) increases the apoptosis rate of B16 murine melanoma cell of treatment at a dose of 5.4 mM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: B16 murine melanoma cells
Concentration: 0.3 mM, 0.7 mM, 1.4 mM, 2.1 mM, 2.9 mM, 3.6 mM, 5.4 mM
Incubation Time: 24 hours, 48 hours or 72 hours
Result: Inhibited the viability of B16 murine melanoma cells in a time- and dose-dependent manner.

Apoptosis Analysis[2]

Cell Line: B16 murine melanoma cells
Concentration: 1.4 mM, 2.9 mM, 5.4 mM
Incubation Time: 24 hours
Result: Caused apoptosis in 19.3% of the cells.
In Vivo

Arbutin (50 mg/kg, 100 mg/kg; oral administration; every day; for 17 days; male C57BL/6 mice) pretreatment exhibits markedly protective effects on ISO-induced cardiac hypertrophy in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice ( 20-25 g)[3]
Dosage: 50 mg/kg, 100 mg/kg
Administration: Oral administration; every day; for 17 days
Result: Ameliorated the ISO-induced myocardial injury.
Clinical Trial
Molecular Weight

272.25

Formula

C₁₂H₁₆O₇

CAS No.

497-76-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (183.65 mM)

H2O : 33.33 mg/mL (122.42 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6731 mL 18.3655 mL 36.7309 mL
5 mM 0.7346 mL 3.6731 mL 7.3462 mL
10 mM 0.3673 mL 1.8365 mL 3.6731 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Arbutinβ-ArbutinTyrosinaseInhibitorinhibitorinhibit

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