2. Metabolic Enzyme/Protease
  3. Tyrosinase Endogenous Metabolite
  4. Arbutin

Arbutin  (Synonyms: β-Arbutin)

Cat. No.: HY-N0192 Purity: ≥98.0%
COA Handling Instructions

Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.

For research use only. We do not sell to patients.

Arbutin Chemical Structure

Arbutin Chemical Structure

CAS No. : 497-76-7

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10 mM * 1 mL in DMSO USD 61 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Arbutin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Arbutin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Arbutin (0.3-5.4 mM; 24 hours, 48 hours, 72 hours; B16 murine melanoma cells) inhibites the viability of B16 murine melanoma cells in a time-and dose-dependent manner[2].
Arbutin (1.4-5.4 mM; 24 hours) increases the apoptosis rate of B16 murine melanoma cell of treatment at a dose of 5.4 mM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Arbutin Related Antibodies

Cell Viability Assay[2]

Cell Line: B16 murine melanoma cells
Concentration: 0.3 mM, 0.7 mM, 1.4 mM, 2.1 mM, 2.9 mM, 3.6 mM, 5.4 mM
Incubation Time: 24 hours, 48 hours or 72 hours
Result: Inhibited the viability of B16 murine melanoma cells in a time- and dose-dependent manner.

Apoptosis Analysis[2]

Cell Line: B16 murine melanoma cells
Concentration: 1.4 mM, 2.9 mM, 5.4 mM
Incubation Time: 24 hours
Result: Caused apoptosis in 19.3% of the cells.
In Vivo

Arbutin (50 mg/kg, 100 mg/kg; oral administration; every day; for 17 days; male C57BL/6 mice) pretreatment exhibits markedly protective effects on ISO-induced cardiac hypertrophy in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice ( 20-25 g)[3]
Dosage: 50 mg/kg, 100 mg/kg
Administration: Oral administration; every day; for 17 days
Result: Ameliorated the ISO-induced myocardial injury.
Clinical Trial
Molecular Weight

272.25

Appearance

Solid

Formula

C12H16O7
CAS No.
SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(O)C=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (183.65 mM)

H2O : 33.33 mg/mL (122.42 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6731 mL 18.3655 mL 36.7309 mL
5 mM 0.7346 mL 3.6731 mL 7.3462 mL
10 mM 0.3673 mL 1.8365 mL 3.6731 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (367.31 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Arbutin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Arbutin497-76-7β-ArbutinTyrosinaseEndogenous MetaboliteInhibitorinhibitorinhibit

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