1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. NecroX-5

NecroX-5 

Cat. No.: HY-104015 Purity: 99.31%
Handling Instructions

NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.

For research use only. We do not sell to patients.

NecroX-5 Chemical Structure

NecroX-5 Chemical Structure

CAS No. : 1383718-29-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 497 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.

IC50 & Target

Calcium channel[1]

In Vitro

NecroX-5 (10 or 40 μM) inhibits breast cancer cell migration, which is correlated with mitoROS reduction, and mediated by AKT inhibition. NecroX-5 (10 μM) decreases intracellular calcium concentration in 4T1 cells by blocking Ca2+ influx, which mediated the inhibition of cell migration, AKT downregulation and the reduction of mitochondrial ROS levels[1]. NecroX-5 (10 µM) treatment for 24 h, effectively decreases the increased TNFα, TGFβ1, pSmad2 and the expression of Dcn in LPS-stimulated H9C2 cells[2].

In Vivo

NecroX-5 (2.5 mg/kg, everyday other day) inhibits breast cancer cell metastasis in TUBO-P2J tumour-bearing mice[1].

Molecular Weight

645.81

Formula

C₂₇H₃₉N₃O₉S₃

CAS No.

1383718-29-3

SMILES

O=S1(CCN(CC2=CC3=C(NC(C4=CC=CC=C4)=C3)C(NCC5CCOCC5)=C2)CC1)=O.CS(=O)(O)=O.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 170 mg/mL (263.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5484 mL 7.7422 mL 15.4844 mL
5 mM 0.3097 mL 1.5484 mL 3.0969 mL
10 mM 0.1548 mL 0.7742 mL 1.5484 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.83 mg/mL (4.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.83 mg/mL (4.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

NecroX-5NecroX5NecroX 5Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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Product name:
NecroX-5
Cat. No.:
HY-104015
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