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Cat. No.: HY-104015A

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NecroX-5 free base

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

NecroX-5 free base is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.

For research use only. We do not sell to patients.

CAS No.: 1120332-90-2
Formula: C₂₅H₃₁N₃O₃S
Molecular Weight:453.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

NecroX-5 free base Chemical Structure

CAS No.: 1120332-90-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

NecroX-5 free base is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.

All Calcium Channel Isoforms :

Chemical Information

CAS No. 1120332-90-2
Molecular Weight 453.60
Formula C₂₅H₃₁N₃O₃S
SMILES

O=S1(CCN(CC1)CC2=CC3=C(C(NCC4CCOCC4)=C2)NC(C5=CC=CC=C5)=C3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Int J Mol Sci

Cytoprotective Mechanism of Necrox-5 Against Toxicity Induced by Experimental Ferroptosis Instigators and the Pesticide Propargite. [Abstract]

2026 Feb 12;27(4):1772. PMID: 41751908
Int Immunopharmacol

NecroX-5 alleviate lipopolysaccharide-induced acute respiratory distress syndrome by inhibiting TXNIP/NLRP3 and NF-κB. [Abstract]

2020 Apr;81:106257. PMID: 32044659

NecroX-5 free base purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2020 Apr;81:106257. [Abstract]

NecroX-5 inhibits the NLRP3 inflammasome activation in macrophages. RAW264.7 cells are firstly pretreated with 20 μM NecroX-5 for 1 h and then stimulated with LPS (1 μg/mL) for 8 h followed by 5 mmol/L of ATP for 30 min. Quantification of western blot in panen D.
FEBS J

Propionibacterium acnes evades microbicidal phagocytosis by inhibiting the mitochondrial biogenesis of nucleus pulposus cells. [Abstract]

2025 Sep 2. PMID: 40891515

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thu VT, et al. NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts. Korean J Physiol Pharmacol. 2016 May;20(3):305-14. [Content Brief]

[2]. Park JH, et al. NecroX-5 prevents breast cancer metastasis by AKT inhibition via reducing intracellular calcium levels. Int J Oncol. 2017 Jan;50(1):185-192. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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NecroX-5 free base

3 Cited Publications

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NecroX-5 free base purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2020 Apr;81:106257. [Abstract]

Customer Validation
NecroX-5 inhibits the NLRP3 inflammasome activation in macrophages. RAW264.7 cells are firstly pretreated with 20 μM NecroX-5 for 1 h and then stimulated with LPS (1 μg/mL) for 8 h followed by 5 mmol/L of ATP for 30 min. Quantification of western blot in panen D.

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NecroX-5 free base

Publications Citing Use of MedChemExpress (MCE) NecroX-5 free base

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Publications (3)

Purity & Documentation

References

Calculators

Help & FAQs

NecroX-5 free base Related Classifications

HY-104015A Related Classifications