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Rubropunctatin 

Cat. No.: HY-N7766
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Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity.

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Rubropunctatin Chemical Structure

Rubropunctatin Chemical Structure

CAS No. : 514-67-0

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Description

Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity[1][2][3].

In Vitro

Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1[1].
Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells[1].
Rubropunctatin (0.75-8.0 µg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity[2].

Cell Viability Assay[1]

Cell Line: BGC-823 and GES-1cells
Concentration: 1.5, 3, 6, 12, 15, 18, 30 μM
Incubation Time: 24 hours
Result: Decreased the viability of BGC-823 cells with an IC50 of 12.57 μM for 24 h.
Did not show obvious cytotoxic effects on the normal cells.

Cell Cycle Analysis[1]

Cell Line: BGC-823 cells
Concentration: 0, 5, 10, 30 μM
Incubation Time: 0, 6, 12, 24 hours
Result: Increased the percentage of cells in sub-G1 phase in a dose- and time-dependent manner.
In Vivo

Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice[1].
Rubropunctamine inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID50 of 0.11 mg/ear[3].

Animal Model: Male nude mice (5 weeks) are inoculated with BGC-823 cells[1]
Dosage: 8, 32 mg/kg
Administration: I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result: Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg).
Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg).
No significant difference was observed on the body weight.
Molecular Weight

354.40

Formula

C₂₁H₂₂O₅

CAS No.

514-67-0

SMILES

O=C(O1)C(C(CCCCC)=O)=C2[[email protected]]1(C)C(C3=COC(/C=C/C)=CC3=C2)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RubropunctatinApoptosisorangeazaphilonepigmentanti-inflammatoryimmunosuppressiveantioxidativeanti-tumorInhibitorinhibitorinhibit

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