Rubropunctatin

Name: Rubropunctatin
Brand: MedChemExpress
SKU: HY-N7766
Rating: 4.5 (1 reviews)

Cat. No.: HY-N7766 Purity: 98.0%: Data Sheet
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Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity.

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Rubropunctatin 화학구조

CAS No. : 514-67-0

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
2 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	견적 받기	Estimated Time of Arrival: December 31
10 mg	견적 받기
50 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Rubropunctatin

•Spectrochim Acta A Mol Biomol Spectrosc. 2026 Jul 5:355:127669. [Abstract]

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	28.2 3 Compound: 9	Antiproliferative activity against human A431 cells after 72 hrs Antiproliferative activity against human A431 cells after 72 hrs	[PMID: 20655237]
A-431	IC₅₀	28.2 3 Compound: 9	Antiproliferative activity against human A431 cells after 72 hrs Antiproliferative activity against human A431 cells after 72 hrs	[PMID: 20655237]
A-431	IC₅₀	28.2 3 Compound: 9	Antiproliferative activity against human A431 cells after 72 hrs Antiproliferative activity against human A431 cells after 72 hrs	[PMID: 20655237]
IGROV-1	IC₅₀	28.2 3 Compound: 9	Antiproliferative activity against human IGROV1 cells after 72 hrs Antiproliferative activity against human IGROV1 cells after 72 hrs	[PMID: 20655237]
IGROV-1	IC₅₀	28.2 3 Compound: 9	Antiproliferative activity against human IGROV1 cells after 72 hrs Antiproliferative activity against human IGROV1 cells after 72 hrs	[PMID: 20655237]
IGROV-1	IC₅₀	28.2 3 Compound: 9	Antiproliferative activity against human IGROV1 cells after 72 hrs Antiproliferative activity against human IGROV1 cells after 72 hrs	[PMID: 20655237]
NCI-H460	IC₅₀	> 50 3 Compound: 9	Antiproliferative activity against human NCI-H460 cells after 72 hrs Antiproliferative activity against human NCI-H460 cells after 72 hrs	[PMID: 20655237]
NCI-H460	IC₅₀	>50 3 Compound: 9	Antiproliferative activity against human NCI-H460 cells after 72 hrs Antiproliferative activity against human NCI-H460 cells after 72 hrs	[PMID: 20655237]
NCI-H460	IC₅₀	> 50 3 Compound: 9	Antiproliferative activity against human NCI-H460 cells after 72 hrs Antiproliferative activity against human NCI-H460 cells after 72 hrs	[PMID: 20655237]

In Vitro

Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1^[1].
Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells^[1].
Rubropunctatin (0.75-8.0 µg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	BGC-823 and GES-1cells
Concentration:	1.5, 3, 6, 12, 15, 18, 30 μM
Incubation Time:	24 hours
Result:	Decreased the viability of BGC-823 cells with an IC₅₀ of 12.57 μM for 24 h. Did not show obvious cytotoxic effects on the normal cells.

Cell Cycle Analysis^[1]

Cell Line:	BGC-823 cells
Concentration:	0, 5, 10, 30 μM
Incubation Time:	0, 6, 12, 24 hours
Result:	Increased the percentage of cells in sub-G1 phase in a dose- and time-dependent manner.

In Vivo

Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice^[1].
Rubropunctamine inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID₅₀ of 0.11 mg/ear^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male nude mice (5 weeks) are inoculated with BGC-823 cells^[1]
Dosage:	8, 32 mg/kg
Administration:	I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result:	Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg). Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg). No significant difference was observed on the body weight.

분자량

354.40

화학식

C₂₁H₂₂O₅

CAS No.

514-67-0

Appearance

Solid

Color

Yellow to orange

SMILES

O=C(O1)C(C(CCCCC)=O)=C2[C@]1(C)C(C3=COC(/C=C/C)=CC3=C2)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Monascus purpureus

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

순도&문서

Purity: 98.0%

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Data Sheet (273 KB) SDS (252 KB)

COA (249 KB) HNMR (272 KB)

Handling Instructions (2659 KB)

References

[1]. Zheng Y, et, al. Anti-cancer effect of rubropunctatin against human gastric carcinoma cells BGC-823. Appl Microbiol Biotechnol. 2010 Nov;88(5):1169-77. [Content Brief]

[2]. Dhale MA, et, al. Protective and antioxidative effect of rubropunctatin against oxidative protein damage induced by metal catalyzed reaction. Int J Biol Macromol. 2018 Sep;116:409-416. [Content Brief]

[3]. Akihisa T, et, al. Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects. J Agric Food Chem. 2005 Feb 9;53(3):562-5. [Content Brief]

Rubropunctatin Related Classifications

몰농도 계산기
농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rubropunctatin514-67-0Apoptosisorangeazaphilonepigmentanti-inflammatoryimmunosuppressiveantioxidativeanti-tumorInhibitorinhibitorinhibit

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Rubropunctatin

고객리뷰

Rubropunctatin Related Antibodies

1 Publications Citing Use of MCE Rubropunctatin

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•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

Rubropunctatin Related Antibodies

Rubropunctatin Related Classifications

몰농도 계산기

농도 희석 계산기

The molarity calculator equation

The dilution calculator equation

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고객리뷰

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