1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Spiraeoside

Spiraeoside (Synonyms: Quercetin 4′-O-glucoside)

Cat. No.: HY-N8253
Handling Instructions

Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities.

For research use only. We do not sell to patients.

Spiraeoside Chemical Structure

Spiraeoside Chemical Structure

CAS No. : 20229-56-5

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Description

Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities[1].

In Vitro

Spiraeoside elevates HG stimulation-caused the decrease in the expression levels of p-Akt, nuclear Nrf2, and HO-1 in AC16 cells (the effects of Spiraeoside are reversed by LY294002)[1].
Spiraeoside protects AC16 cells against HG-induced oxidative stress, cell injury, and apoptosis[1].
Spiraeoside activates the PI3K/Akt/Nrf2 pathway in AC16 cells on exposure to HG[1].
Spiraeoside protects AC16 cells against HG-induced apoptosis through the PI3K/Akt/Nrf2 pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: AC16 cells.
Concentration: 1, 5, 10, or 20 μM.
Incubation Time: 0, 24, or 48 hours.
Result: Inhibited AC16 cells viability (20 μM).
In Vivo

Spiraeoside (50 mg/kg, p.o.) shows ulcer preventive ability[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (6-8 weeks old)[2].
Dosage: 50 mg/kg.
Administration: Oral gavage an hour before inducing the lesions.
Result: Decreased severity of the formed lesions.
Molecular Weight

464.38

Formula

C₂₁H₂₀O₁₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Spiraeoside
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HY-N8253
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