PTD-p65-P1 Peptide
Based on 3 publication(s) in Google Scholar
PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.
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- Formel: C168H275N57O44S
- Molecular Weight:3829.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) PTD-p65-P1 Peptide
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Biologische Aktivität
NF-kappaB[1]
PTD-p65-P1 Peptide (10-150 μM; 0-60 min; KBM-5 cells) inhibits TNF-induced NF-κB activation in a dose-dependent manner and suppresses TNF-induced NF-κB activation by 25% at 100 μM and completely at 150 μM[1].
PTD-p65-P1 Peptide (150 μM; 0-60 min; KBM-5 cells) inhibits cytoplasmic p65 phosphorylation and nuclear translocation[1].
PTD-p65-P1 Peptide (100 μM; 16 h; KBM-5 cells) potentiates the TNF-induced apoptosis from 4 to 45%[1].
PTD-p65-P1 Peptide (150 μM; A 293 cells) inhibits NF-κB-dependent reporter gene expression induced by TNF[1].
PTD-p65-P1 Peptide (150 μM; 12-24 h; SP-53 cells ) inhibits the cell proliferation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KBM-5 cells
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Concentration:150 μM
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Incubation Time:0, 5, 10, 15, 30 and 60 minutes
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Result:Suppressed TNF-induced NF-κB activation by inhibiting phosphorylation and nuclear translocation of p65.
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Cell Line:SP-53 cells
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Concentration:150 μM
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Incubation Time:12 and 24 hours
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Result:Inhibited cell proliferation of 40% in 12 hours and 60% in 24 hours.
Chemical Information
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Molecular Weight 3829.50
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Formel C168H275N57O44S
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Sequence Shortening
DRQIKIWFQNRRMKWKKQLRRPSDRELSE
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
2023 Mar 10;14(3):188. PMID: 36898991 -
Cell Cycle
2022 Oct;21(20):2132-2144. PMID: 35762530 -
Cell Biochem Biophys
Inhibited Expression of NLRP12 Promotes the Development of Triple-Negative Breast Cancer by Activating the NF-κB Pathway. [Abstract]2023 Dec;81(4):727-735. PMID: 37658975
Reinheit & Dokumentation
Verweise
[1]. Takada Y, et, al. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem. 2004 Apr 9;279(15):15096-104. [Content Brief]
[2]. Shishodia S, et, al. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol. 2005 Sep 1;70(5):700-13. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PTD-p65-P1 Peptide Related Classifications
HY-P1832 Related Classifications
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