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  3. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside  (Synonyms: 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside)

Cat. No.: HY-N0652 Purity: 99.20%
COA Handling Instructions

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions.

For research use only. We do not sell to patients.

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside Chemical Structure

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside Chemical Structure

CAS No. : 82373-94-2

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 55 In-stock
Solid
5 mg USD 32 In-stock
10 mg USD 50 In-stock
25 mg USD 100 In-stock
50 mg USD 140 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside

WB

    2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside purchased from MedChemExpress. Usage Cited in: Molecules. 2020 Jul 6;25(13):3070.  [Abstract]

    Cytochrome c is analyzed by Western blotting in cytosolic and mitochondrial fractions. THSG treatment blocks the release of cytochrome c from mitochondria to the cytosol.

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    • Customer Review

    Description

    2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions[1][2].

    In Vitro

    2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside (5-80 μM, 2 h) inhibits LPS-induced expression of pro-inflammatory cytokine (IL-6 and TNF-α) in RAW264.7 cells[3].
    2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside (5-80 μM, 2 h) inhibits the expression of NO and mRNA levels of proinflammatory cytokine (IL-1β, IL-6, TNF-α and COX-2. ) in RAW264.7 cells[3].
    2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside (5-80 μM, 2 h) suppresses NF-κB signaling pathway and ERK2 activation in LPS-induced RAW264.7 cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Western Blot Analysis[3]

    Cell Line: RAW264.7 cells
    Concentration: 5-80 μM
    Incubation Time: 2 h
    Result: Reduced the phosphorylation level of ERK2, IκBα, IKKβ, and NF-κB p65 in a dosedependent manner.
    Attenuated LPS-induced nuclear translocation with a dose-dependent behavior.
    In Vivo

    2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside (30-60 mg/kg, i.p., daily, 7 days) can be used to cope with depressive-like symptoms in male ICR mice by inhibition of neuroinflammation and oxido-nitrosative stress[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male ICR mice[2]
    Dosage: 30-60 mg/kg
    Administration: i.p., daily, 7 days
    Result: Inhibited the production of proinflammatory cytokines induced by LPS, such as interleukin-1β, interleukin-6, and tumor necrosis factor-α.
    Prevented the LPS-induced enhancement of oxido-nitrosative stress in mouse hippocampus and prefrontal cortex.
    Prevented LPS-induced decreases in brain-derived neurotrophic factor levels in the hippocampus and prefrontal cortex.
    Molecular Weight

    406.39

    Formula

    C20H22O9

    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    OC1=CC(O)=CC(/C=C/C2=CC=C(O)C=C2)=C1O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (246.07 mM; Need ultrasonic)

    H2O : 10 mg/mL (24.61 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4607 mL 12.3035 mL 24.6069 mL
    5 mM 0.4921 mL 2.4607 mL 4.9214 mL
    10 mM 0.2461 mL 1.2303 mL 2.4607 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 16.67 mg/mL (41.02 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (5.12 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (5.12 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (5.12 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.20%

    References
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    2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside
    Cat. No.:
    HY-N0652
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