Anti-inflammatory agent 14
Anti-inflammatory agent 14 (compound 28) is an anti-inflammatory agent, with a MIC50 of 2 μM for Mtb H37Rv.
For research use only. We do not sell to patients.
- CAS No.: 894496-27-6
- Formula: C16H16N2O2S
- Molecular Weight:300.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
13.7 μM
Compound: 28
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Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
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[PMID: 34890996] |
| RAW264.7 | IC50 |
20.7 μM
Compound: 28
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Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
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[PMID: 34890996] |
| RAW264.7 | IC50 |
33.2 μM
Compound: 28
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Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
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[PMID: 34890996] |
| RAW264.7 | CC50 |
≥200 μM
Compound: 28
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Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
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[PMID: 34890996] |
Anti-inflammatory agent 14 (compound 28) inhibits IL-1β dose-dependently[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 894496-27-6
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Molecular Weight 300.38
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Formula C16H16N2O2S
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SMILES
S=C(NCC1=CC=CC=C1)NC2=CC=C3OCCOC3=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 14 Related Classifications
HY-144735 Related Classifications
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