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AUDA 

Cat. No.: HY-108570
Handling Instructions

AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50s of 18 and 69 nM for the mouse and human sEH, respectively. AUDA has anti-inflammatory activity.

For research use only. We do not sell to patients.

AUDA Chemical Structure

AUDA Chemical Structure

CAS No. : 479413-70-2

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Description

AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50s of 18 and 69 nM for the mouse and human sEH, respectively[1]. AUDA has anti-inflammatory activity[2].

IC50 & Target

IC50: 18 nM (mouse sEH) and 69 nM (human sEH)[1]

In Vitro

AUDA (0.3-10 μg/mL; 48 hours) dose-dependently suppresses the proliferation of rat VSMCs exposed to PDGF[2].
AUDA (0.3-10 μg/mL; 30 min) dose-dependently upregulats COX-2 expression[2].
AUDA (10, 50 and 100 μM) augments the migratory ability of HCAECs in a dose-dependent manner[3].
AUDA significantly increases the adhesion ability of HCAECs[3].

Cell Proliferation Assay[2]

Cell Line: Vascular smooth muscle cell (VSMC)
Concentration: 0.3, 1, 3, 10 μg/mL
Incubation Time: 48 hours
Result: Dose-dependently suppressed the proliferation of rat VSMCs exposed to PDGF.

Western Blot Analysis[2]

Cell Line: VSMC
Concentration: 1, 3, 10, 30 μg/mL
Incubation Time: 30 min
Result: Dose-dependently upregulated COX-2 expression.
In Vivo

AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels[3].

Animal Model: Male (wild-type) C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g)[3]
Dosage: 10 mg/kg
Administration: i.p.; 14 days
Result: Reduced TNF-α, MMP-9 and IL-1β expression levels.
Molecular Weight

392.58

Formula

C₂₃H₄₀N₂O₃

CAS No.

479413-70-2

SMILES

O=C(O)CCCCCCCCCCCNC(NC1(C2)CC3CC2CC(C3)C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AUDAOtherssolubleepoxidehydrolasesEHanti-inflammatoryactivityVSMCInhibitorinhibitorinhibit

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