1. Alkaloids
  2. Mahanimbine

Mahanimbine 

Cat. No.: HY-124557
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Mahanimbine is an orally active alkaloid from curry leaves. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice.

For research use only. We do not sell to patients.

Mahanimbine Chemical Structure

Mahanimbine Chemical Structure

CAS No. : 21104-28-9

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Description

Mahanimbine is an orally active alkaloid from curry leaves. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice[1].

In Vivo

Mahanimbine (2-4 mg/kg; p.o.; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female)[1].
Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress[1].
Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin responsive genes in liver and adipose tissue[1].

Animal Model: Swiss albino mice (7-8 weeks old, both sex)[1]
Dosage: HFD+LD (2 mg/kg of body weight of mahanimbine), HFD+HD (4 mg/kg of body weight of mahanimbine);
Administration: Oral suspension; daily for 12 weeks
Result: Male HFD+LD and HFD+HD groups showed 51.70±6 3.59% and 47.37±3.73% weight gain, respectively, as compared with 71.02±6 6.04% in HFD fed mice whereas female HFD+LD and HFD+HD groups showed 24.31±1.68% and 25.10±2.61% weight gain as compared with HFD group with 36.69±3.60% of weight gain.
Molecular Weight

331.45

Formula

C₂₃H₂₅NO

CAS No.

21104-28-9

SMILES

C/C(C)=C\CC[[email protected]]1(C)OC(C(C)=CC2=C3NC4=C2C=CC=C4)=C3C=C1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MahanimbineOthershigh-fat dietmetabolicalkaloidinflammatoryinsulinglucoseclearanceInhibitorinhibitorinhibit

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Mahanimbine
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