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  6. 5'-Methoxynobiletin

5'-Methoxynobiletin is a potent and orally active antinociceptive and anti-inflammatory agent. 5'-Methoxynobiletin is a polymethoxyflavone, that can be isolated from A. conyzoides.

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5'-Methoxynobiletin Chemical Structure

5'-Methoxynobiletin Chemical Structure

CAS No. : 6965-36-2

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5'-Methoxynobiletin Related Antibodies

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Description

5'-Methoxynobiletin is a potent and orally active antinociceptive and anti-inflammatory agent. 5'-Methoxynobiletin is a polymethoxyflavone, that can be isolated from A. conyzoides[1][2].

In Vivo

5'-Methoxynobiletin (5 mg/kg, IP) signifcantly decreases leukocyte counting, neutrophil infux and protein concentration in the exudate, as well as reduced the levels of several pro-infammatory mediators[2].
5'-Methoxynobiletin (100 mg/kg, Orally, once) shows anti-nociceptive and anti-inflammatory activity[2].
5'-Methoxynobiletin (10 mg/kg (IV), 50 mg/kg (oral), once) showed a low oral bioavailability in rats, around 8-11%[2].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice (female)[2]
Dosage: 100 mg/kg
Administration: Orally
Result: Significantly reduced both phases of formalin-induced nocifensive behavior after 15, 30 and 60 min of oral administration, when compared to control groups. In the neurogenic phase, inhibitions of 43±3%, 68±6% and 53±5% of the nociceptive response were observed, while for the infammatory phase inhibitions were 70±8%, 91±3% and 85±3% after 15, 30 and 60 min of the oral administration of 5'-Methoxynobiletin, respectively.
Animal Model: Wistar rats (male)[2]
Dosage: 10 mg/kg (IV), 50 mg/kg (oral)
Administration: IV, oral, once (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of 5'-Methoxynobiletin in male Wistar rats[1].
IV (10 mg/kg) IG (50 mg/kg)
λ (h-1) 0.55±0.03 0.29±0.2
Tmax (h) 2.71±0.49
Cmax (mg/L) 0.62±0.21
AUC0-∞ (mg·h/L) 8.19±4.1 3.65±0.8
t1/2 elimination (h) 1.26±0.1 2.31±0.9
CL (L/h.kg) 1.22±0.26 13.68±0.29
Vd, ss (L/kg) 2.24±0.32 47.46±10.10
F (%) 8.67
Molecular Weight

432.42

Formula

C22H24O9
CAS No.
SMILES

O=C1C=C(C2=CC(OC)=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5'-Methoxynobiletin6965-36-2OthersAgeratum conyzoidesAnti-inflammatoryAntinociceptiveEupalestinInhibitorinhibitorinhibit

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