2. Anti-infection
  3. Bacterial
  4. 5'-Methoxynobiletin

5'-Methoxynobiletin is a potent and orally active antinociceptive and anti-inflammatory agent. 5'-Methoxynobiletin is a polymethoxyflavone, that can be isolated from A. conyzoides.

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5'-Methoxynobiletin

5'-Methoxynobiletin Chemical Structure

CAS No. : 6965-36-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

5'-Methoxynobiletin Related Antibodies

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Description

5'-Methoxynobiletin is a potent and orally active antinociceptive and anti-inflammatory agent. 5'-Methoxynobiletin is a polymethoxyflavone, that can be isolated from A. conyzoides[1][2].

Cellular Effect
Cell Line Type Value Description References
KB ED50
0.5 μg/mL
Compound: NSC-67580
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
[PMID: 469554]
In Vivo

5'-Methoxynobiletin (5 mg/kg, IP) signifcantly decreases leukocyte counting, neutrophil infux and protein concentration in the exudate, as well as reduced the levels of several pro-infammatory mediators[2].
5'-Methoxynobiletin (100 mg/kg, Orally, once) shows anti-nociceptive and anti-inflammatory activity[2].
5'-Methoxynobiletin (10 mg/kg (IV), 50 mg/kg (oral), once) showed a low oral bioavailability in rats, around 8-11%[2].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice (female)[2]
Dosage: 100 mg/kg
Administration: Orally
Result: Significantly reduced both phases of formalin-induced nocifensive behavior after 15, 30 and 60 min of oral administration, when compared to control groups. In the neurogenic phase, inhibitions of 43±3%, 68±6% and 53±5% of the nociceptive response were observed, while for the infammatory phase inhibitions were 70±8%, 91±3% and 85±3% after 15, 30 and 60 min of the oral administration of 5'-Methoxynobiletin, respectively.
Animal Model: Wistar rats (male)[2]
Dosage: 10 mg/kg (IV), 50 mg/kg (oral)
Administration: IV, oral, once (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of 5'-Methoxynobiletin in male Wistar rats[1].
IV (10 mg/kg) IG (50 mg/kg)
λ (h-1) 0.55±0.03 0.29±0.2
Tmax (h) 2.71±0.49
Cmax (mg/L) 0.62±0.21
AUC0-∞ (mg·h/L) 8.19±4.1 3.65±0.8
t1/2 elimination (h) 1.26±0.1 2.31±0.9
CL (L/h.kg) 1.22±0.26 13.68±0.29
Vd, ss (L/kg) 2.24±0.32 47.46±10.10
F (%) 8.67
Molecular Weight

432.42

Formula

C22H24O9
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C=C(C2=CC(OC)=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (144.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3126 mL 11.5628 mL 23.1257 mL
5 mM 0.4625 mL 2.3126 mL 4.6251 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.73%

SDS (252 KB)

COA (252 KB) HNMR (264 KB) LCMS (102 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3126 mL 11.5628 mL 23.1257 mL 57.8142 mL
5 mM 0.4625 mL 2.3126 mL 4.6251 mL 11.5628 mL
10 mM 0.2313 mL 1.1563 mL 2.3126 mL 5.7814 mL
15 mM 0.1542 mL 0.7709 mL 1.5417 mL 3.8543 mL
20 mM 0.1156 mL 0.5781 mL 1.1563 mL 2.8907 mL
25 mM 0.0925 mL 0.4625 mL 0.9250 mL 2.3126 mL
30 mM 0.0771 mL 0.3854 mL 0.7709 mL 1.9271 mL
40 mM 0.0578 mL 0.2891 mL 0.5781 mL 1.4454 mL
50 mM 0.0463 mL 0.2313 mL 0.4625 mL 1.1563 mL
60 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9636 mL
80 mM 0.0289 mL 0.1445 mL 0.2891 mL 0.7227 mL
100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.5781 mL
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5'-Methoxynobiletin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5'-Methoxynobiletin6965-36-2BacterialAgeratum conyzoidesAnti-inflammatoryAntinociceptiveEupalestinInhibitorinhibitorinhibit

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