1. Immunology/Inflammation
  2. COX
  3. Tolmetin

Tolmetin 

Cat. No.: HY-B1799 Purity: >98.0%
Handling Instructions

Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 µM and 0.82 µM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID).

For research use only. We do not sell to patients.

Tolmetin Chemical Structure

Tolmetin Chemical Structure

CAS No. : 26171-23-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 µM and 0.82 µM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID)[1][2].

IC50 & Target[1]

Human COX-1

0.35 μM (IC50)

Human COX-2

0.82 μM (IC50)

In Vitro

Tolmetin (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat[3].
Tolmetin (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner[4].
Tolmetin (0-100 μM) shows no effect on osteoblast growth[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tolmetin (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg[2].
Tolmetin (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

257.28

Formula

C₁₅H₁₅NO₃

CAS No.

26171-23-3

SMILES

O=C(O)CC1=CC=C(C(C2=CC=C(C)C=C2)=O)N1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (388.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8868 mL 19.4341 mL 38.8682 mL
5 mM 0.7774 mL 3.8868 mL 7.7736 mL
10 mM 0.3887 mL 1.9434 mL 3.8868 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.72 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.72 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.72 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TolmetinCOXCyclooxygenasenon-steroidalanti-inflammatoryNSAIDanticancerneurotoxicityInhibitorinhibitorinhibit

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Tolmetin
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