1. Immunology/Inflammation
  2. COX

Tolmetin sodium dihydrate 

Cat. No.: HY-B1489 Purity: 99.77%
Handling Instructions

Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.

For research use only. We do not sell to patients.

Tolmetin sodium dihydrate Chemical Structure

Tolmetin sodium dihydrate Chemical Structure

CAS No. : 64490-92-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.

IC50 & Target[1]

COX

 

In Vitro

Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent. Tolmetin (0-100 μM) shows no effect on osteoblast growth[2]. Tolmetin (0.25 mM) dose not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat[3].

In Vivo

Tolmetin (100 mg/kg) causes gastric lesions, and shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration. Tolmetin produces obvious endothelial damage and inflammatory cell infiltration[1]. Tolmetin (5 mg/kg, i.p., twice a day for 5 days) has no effect on n NMDA receptor binding in rats[3].

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (317.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1716 mL 15.8579 mL 31.7158 mL
5 mM 0.6343 mL 3.1716 mL 6.3432 mL
10 mM 0.3172 mL 1.5858 mL 3.1716 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Rats[1]
After 2 weeks of acclimatization, rats are randomized to different groups and given the non-selective COX inhibitors, amtolmetin guacyl (AMG) (50 and 150 mg/kg) and Tolmetin (30 and 100 mg/kg) as well as the selective COX-2 inhibitor, celecoxib (CXIB; 20 and 60 mg/kg). The compounds are suspended in 1% carboxymethylcellulose (CMC) immediately before use and administered by gavage in a 10-mL/kg volume. Control groups receive CMC in the same volume. Rats from each group are divided into 3 subgroups, consisting each of at least 10 animals. Subgroups are dosed either with a single dose (acute treatment group) or twice daily for 3 and 14 days (chronic treatment groups). To ensure that all groups are dosed for the same period of time, those receiving less than 14 days of NSAIDs are given CMC until they are due to start the assigned treatment. Rats are killed by cervical dislocation 4 h after the last administration. Stomachs are immediately removed, opened along the lesser curvature and gently rinsed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

315.30

Formula

C₁₅H₁₈NNaO₅

CAS No.

64490-92-2

SMILES

O=C([O-])CC1=CC=C(C(C2=CC=C(C)C=C2)=O)N1C.[Na+].O.O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Tolmetin sodium dihydrate
Cat. No.:
HY-B1489
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Tolmetin sodium dihydrate

Cat. No.: HY-B1489