CTP Synthetase-IN-1
Based on 1 Customer Validation
CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase-IN-1 has anti-inflammatory effects.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 2338811-71-3
- Formula: C20H19F3N6O3S2
- Molecular Weight:512.53
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 32 nM (human CTPS1) and 18 nM (human CTPS2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat E6.1 | IC50 |
18 μM
Compound: 27; T35
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Antiproliferative activity against human Jurkat E6.1 cells after 3 days by luminescence based CellTiter-glo assay
Antiproliferative activity against human Jurkat E6.1 cells after 3 days by luminescence based CellTiter-glo assay
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[PMID: 36449304] |
CTP Synthetase-IN-1 (compound 27) inhibits rat CTPS1, rat CTPS2, mouse CTPS1, and mouse CTPS2 with IC50 values of 27 nM, 23 nM, 26 nM, and 33 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse collagen-induced arthritis (CIA) model[1]
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Dosage:10 mg/kg and 50 mg/kg
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Administration:p.o; twice daily; for 18 days
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Result:Resulted in improvements in specific indicators of disease severity.
Chemical Information
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CAS No. 2338811-71-3
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Appearance Solid
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Molecular Weight 512.53
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Formula C20H19F3N6O3S2
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Color White to off-white
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SMILES
O=C(C(C)(C)C1=CSC(NS(=O)(C2CC2)=O)=N1)NC3=NC=C(C4=NC(C(F)(F)F)=CN=C4)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (195.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9511 mL | 9.7555 mL | 19.5111 mL | 48.7776 mL |
| 5 mM | 0.3902 mL | 1.9511 mL | 3.9022 mL | 9.7555 mL | |
| 10 mM | 0.1951 mL | 0.9756 mL | 1.9511 mL | 4.8778 mL | |
| 15 mM | 0.1301 mL | 0.6504 mL | 1.3007 mL | 3.2518 mL | |
| 20 mM | 0.0976 mL | 0.4878 mL | 0.9756 mL | 2.4389 mL | |
| 25 mM | 0.0780 mL | 0.3902 mL | 0.7804 mL | 1.9511 mL | |
| 30 mM | 0.0650 mL | 0.3252 mL | 0.6504 mL | 1.6259 mL | |
| 40 mM | 0.0488 mL | 0.2439 mL | 0.4878 mL | 1.2194 mL | |
| 50 mM | 0.0390 mL | 0.1951 mL | 0.3902 mL | 0.9756 mL | |
| 60 mM | 0.0325 mL | 0.1626 mL | 0.3252 mL | 0.8130 mL | |
| 80 mM | 0.0244 mL | 0.1219 mL | 0.2439 mL | 0.6097 mL | |
| 100 mM | 0.0195 mL | 0.0976 mL | 0.1951 mL | 0.4878 mL |
CTP Synthetase-IN-1 Related Classifications
HY-152149 Related Classifications
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