2. Natural Products
  3. Disease Research Fields Plants Terpenoids
  4. Celastraceae Inflammation/Immunology Triterpenes
  5. Tripterygium wilfordii Hook. f.
  6. Wilforlide A

Wilforlide A  (Synonyms: Regelide; Abruslactone A)

Cat. No.: HY-N0476 Purity: 98.0%
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Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects.

For research use only. We do not sell to patients.

Wilforlide A

Wilforlide A Chemical Structure

CAS No. : 84104-71-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Wilforlide A:

Wilforlide A Related Antibodies

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Description

Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects[1].

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
> 60 μM
Compound: Wilforlide A
Cytotoxicity against human A2780 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 38964974]
In Vivo

Wilforlide A (60-300 μg/kg) markedly inhibits mice auricular swelling induced by dimethylbenzene in ICR mice. Wilforlide A exhibits inhibition rates with 50.9% and 12.29% for high dose and low dose Wilforlide A, resepectively[1]. Wilforlide A (30-150 μg/kg) markedly inhibits rat granulation induced by tampon[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

454.68

Formula

C30H46O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1(C2=O)C[C@]([H])(O2)[C@]3(C)CC[C@@]4(C)[C@]5(C)CC[C@@]6([H])C(C)(C)[C@@H](O)CC[C@]6(C)[C@@]5([H])CC=C4[C@]3([H])C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (2.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1993 mL 10.9967 mL 21.9935 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1993 mL 10.9967 mL 21.9935 mL 54.9837 mL
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Wilforlide A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Wilforlide A84104-71-2Regelide Abruslactone AOthersanti-inflammatoryimmunesuppressiveInhibitorinhibitorinhibit

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