1. Immunology/Inflammation
  2. NO Synthase
  3. AR-C102222 hydrochloride

AR-C102222 hydrochloride 

Cat. No.: HY-12122A Purity: >98.0%
Handling Instructions

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities.

For research use only. We do not sell to patients.

AR-C102222 hydrochloride Chemical Structure

AR-C102222 hydrochloride Chemical Structure

CAS No. : 1781934-50-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 530 In-stock
Estimated Time of Arrival: December 31
1 mg USD 190 In-stock
Estimated Time of Arrival: December 31
5 mg USD 575 In-stock
Estimated Time of Arrival: December 31
10 mg USD 980 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM[1]. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities[2].

In Vivo

AR-C102222 (3, 10, 30, 100 mg/kg, P.O.) attenuates arachidonic acid-induced ear inflammation and possesses anti-inflammatory activity[2].
AR-C102222 shows good efficacy in a rat adjuvant-induced arthritis model[3].

Animal Model: Male Balb/c mice (20-25 g)[2].
Dosage: 3, 10, 30, 100 mg/kg.
Administration: P.O. 55 min before the administration of 0.6% acetic acid (i.p., 1 mL/100 g volume).
Result: Significantly inhibited arachidonic acid-induced ear inflammation following a dose of 100 mg/kg of has a maximal inhibition of approximately 79%.
Molecular Weight

418.83

Formula

C₁₉H₁₇ClF₂N₆O

CAS No.

1781934-50-6

SMILES

N#CC1=NC=C(C(N2CCC3(NC4=C(C(F)=CC=C4F)C(N)=N3)CC2)=O)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

AR-C102222NO SynthaseNitric oxide synthasesNOSAntinociceptionArthritisInhibitorinhibitorinhibit

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Product name:
AR-C102222 hydrochloride
Cat. No.:
HY-12122A
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