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AR-C102222

AR-C102222 is a spirocyclic fluoropiperidine quinazoline selective iNOS inhibitor. AR-C102222 can be used for the research of neuropathic pain.

For research use only. We do not sell to patients.

CAS No.: 253771-21-0
Formula: C₁₉H₁₆F₂N₆O
Molecular Weight:382.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

AR-C102222 Chemical Structure

CAS No.: 253771-21-0

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Sample (0.1mg)

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(In Japan)

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

AR-C102222 is a spirocyclic fluoropiperidine quinazoline selective iNOS inhibitor. AR-C102222 can be used for the research of neuropathic pain^[1].

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	0.9 μM Compound: 25	Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells	[PMID: 12620067]
DLD-1	IC₅₀	1 μM Compound: 1, AR-C102222	Inhibition of iNOS in intact human DLD1 cells assessed as nitric oxide production Inhibition of iNOS in intact human DLD1 cells assessed as nitric oxide production	[PMID: 21398123]
DLD-1	IC₅₀	170 nM Compound: 3	Inhibition of human iNOS expressed in human DLD1 cells after 1 hr Inhibition of human iNOS expressed in human DLD1 cells after 1 hr	[PMID: 18024030]
DLD-1	IC₅₀	210 nM Compound: 3	Inhibition of cytokine-induced iNOS activity in human DLD1 cells after 24 hrs Inhibition of cytokine-induced iNOS activity in human DLD1 cells after 24 hrs	[PMID: 18024030]
Sf9	IC₅₀	840 nM Compound: 3	Inhibition of human nNOS expressed in insect SF9 cells after 1 hr Inhibition of human nNOS expressed in insect SF9 cells after 1 hr	[PMID: 18024030]

Chemical Information

CAS No. 253771-21-0
Molecular Weight 382.37
Formula C₁₉H₁₆F₂N₆O
SMILES

N#CC1=NC=C(C(N2CCC3(NC4=C(C(F)=CC=C4F)C(N)=N3)CC2)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chris Walpole, et al. Diastereoselective synthesis of fluorinated piperidine quinazoline spirocycles as iNOS selective inhibitors. Tetrahedron Letters. Volume 53, Issue 24, 13 June 2012, Pages 2942-2947.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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