The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

  • Bioorg Med Chem Lett. 2011 Apr 15;21(8):2468-71. doi: 10.1016/j.bmcl.2011.02.061.
David R Cheshire  1 ,  Anders Åberg ,  Gunilla M K Andersson ,  Glen Andrews ,  Haydn G Beaton ,  Timothy N Birkinshaw ,  Nigel Boughton-Smith ,  Stephen Connolly ,  Tony R Cook ,  Anne Cooper ,  Sally L Cooper ,  David Cox ,  John Dixon ,  Nigel Gensmantel ,  Peter J Hamley ,  Richard Harrison ,  Paul Hartopp ,  Helena Käck ,  Paul D Leeson ,  Timothy Luker ,  Antonio Mete ,  Ian Millichip ,  David J Nicholls ,  Austen D Pimm ,  Steve A St-Gallay ,  Alan V Wallace
Affiliations
  • 1. Department of Chemistry, AstraZeneca Charnwood, Bakewell Road, Loughborough LE11 5RH, United Kingdom. [email protected]
PMID: 21398123 DOI: 10.1016/j.bmcl.2011.02.061
Abstract

By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.