1. Membrane Transporter/Ion Channel
  2. P2X Receptor
  3. Ro-51

Ro-51 

Cat. No.: HY-14485
Handling Instructions

Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain.

For research use only. We do not sell to patients.

Ro-51 Chemical Structure

Ro-51 Chemical Structure

CAS No. : 1050670-85-3

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Description

Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain[1][2].

IC50 & Target

IC50: 2 nM (P2X3), 5 nM (P2X2/3)[1]

In Vitro

Ro-51 has highly selective for P2X 3 and P2X 2/3 exhibiting no antagonistic activity at other P2X receptor family members tested (P2X 1 , P2X 2 , P2X 4 , P2X 5 , and P2X 7 ) at concentrations up to 10 μM[1].
RO51 also shows a significant drop in potency on human P2X3 receptors (IC50 = 110.5 and 0.04 nM, respectively for human and rat P2X3)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ro-51 suffers rapid clearance, short half-lives, and high protein binding in rat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 2 mg/kg (Pharmacokinetic Analysis)
Administration: Oral administration
Result: AUC= 237 ng/h/mL, T 1/2 =1.52 h
Molecular Weight

474.29

Formula

C₁₇H₂₃IN₄O₄

CAS No.

1050670-85-3

SMILES

OCC(NC1=NC=C(OC2=CC(I)=C(OC)C=C2C(C)C)C(N)=N1)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ro-51Ro51Ro 51P2X ReceptorP2XRsP2X(3)P2X(2/3)painhyperalgesiamechanicalallodyniainflammatoryneuropathicmodelsInhibitorinhibitorinhibit

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Ro-51
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HY-14485
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