1. Membrane Transporter/Ion Channel
  2. P2X Receptor
  3. 5-BDBD

5-BDBD 

Cat. No.: HY-101911 Purity: 96.76%
Handling Instructions

5-BDBD, a potent and selective P2X4 receptor antagonist, inhibits rP2X4R-mediated currents, with an IC50 of 0.75 μM. 5-BDBD completely blocks the basal and acute hyperalgesia induced by nitroglycerin (NTG).

For research use only. We do not sell to patients.

5-BDBD Chemical Structure

5-BDBD Chemical Structure

CAS No. : 768404-03-1

Size Price Stock Quantity
5 mg USD 105 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 690 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

5-BDBD, a potent and selective P2X4 receptor antagonist, inhibits rP2X4R-mediated currents, with an IC50 of 0.75 μM. 5-BDBD completely blocks the basal and acute hyperalgesia induced by nitroglycerin (NTG)[1][2].

IC50 & Target

I50: 0.75 μM (P2X4 receptor)

In Vitro

5-BDBD inhibits 10 µM ATP-induced currents of rP2X4R-expressing HEK293 cells in a concentration-dependent manner, with an IC50 of 0.75 μM[1].
5-BDBD displaces rightward the ATP concentration-response curve, with an EC50 of 4.7 to 15.9 μM[1].
5-BDBD could be specifically used to discriminate between P2X1R, P2X2aR, P2X2bR, P2X3R, P2X4R, and P2X7R[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

5-BDBD (28 mg/kg; i.p.; daily for 9 days) can completely blocke the basal hyperalgesia induced by recurrent NTG injection[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice[2]
Dosage: 28 mg/kg
Administration: I.p.; daily for 9 days
Result: Prevented NTG-induced mechanical hypersensitivity.
Molecular Weight

355.19

Formula

C₁₇H₁₁BrN₂O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (175.96 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8154 mL 14.0770 mL 28.1539 mL
5 mM 0.5631 mL 2.8154 mL 5.6308 mL
10 mM 0.2815 mL 1.4077 mL 2.8154 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.86 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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5-BDBD
Cat. No.:
HY-101911
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