1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. P2X Receptor
    Calcium Channel
  3. BX430

BX430 

Cat. No.: HY-110237
Handling Instructions

BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.

For research use only. We do not sell to patients.

BX430 Chemical Structure

BX430 Chemical Structure

CAS No. : 688309-70-8

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Description

BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.

IC50 & Target

IC50: 0.54 μM (human P2X4 receptor channels)[1]

In Vitro

BX430 has virtually no functional impact on all other P2X subtypes, namely, P2X1-P2X3, P2X5, and P2X7, at 10-100 times its IC50[1].
BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs[1].
Human P2X4-expressing cells treated with thapsigargin plus BX430 shows a significant reduction in the intracellular calcium rise evoked by ATP[1].
BX430 (5 μM) markedly reduces the amplitude of ATP-evoked intracellular calcium responses in THP-1 cells[1].

Molecular Weight

413.11

Formula

C₁₅H₁₅Br₂N₃O

CAS No.

688309-70-8

SMILES

O=C(NC1=CC=CN=C1)NC2=C(Br)C=C(C(C)C)C=C2Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BX430BX 430BX-430P2X ReceptorCalcium ChannelP2XRsCa2+ channelsCa channelshumanP2X4receptorchannelsspeciesspecificitychronicpaincardiovasculardiseaseInhibitorinhibitorinhibit

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