AZ10606120 dihydrochloride
Based on 2 publication(s) in Google Scholar
AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of about 10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 607378-18-7
- Formula: C25H36Cl2N4O2
- Molecular Weight:495.48
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) AZ10606120 dihydrochloride
MoreAll P2X Receptor Isoforms
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Biological Activity
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P2X7 Receptor |
AZ10606120 (1-100 μM, 72 h) dihydrochloride depletes tumour cells in patient-derived primary glioblastoma samples[2].
AZ10606120 (1-100 μM, 72 h) dihydrochloride increases Lactate dehydrogenase (LDH) levels in human primary glioblastoma cultures[2].
AZ10606120 (10 μM) dihydrochloride reduces proliferation (60 h), cell migration (1 h) and invasion (24 h) in PDAC cell lines[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AZ10606120 (2 mg/kg i.p.) dihydrochloride shows an antidepressant phenotype in LPS-induced anhedonia mice[5].
AZ10606120 (5 mg/kg, i.m.) dihydrochloride and DNR (0.75 mg/kg, i.m.) combined administration is more effective in reducing HL-60 tumor growth in nude mice in comparison to their single administration[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS-induced anhedonia mice[5]
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Dosage:2 mg/kg
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Administration:i.p., pretreated at 30 min before LPS injection
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Result:Restored the decline in sucrose consumption, indicated by an sucrose preference test (SPT).
Chemical Information
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CAS No. 607378-18-7
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Appearance Solid
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Molecular Weight 495.48
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Formula C25H36Cl2N4O2
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Color White to off-white
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SMILES
O=C(NC1=C2C=CC(NCCNCCO)=NC2=CC=C1)CC3(C4)CC5CC4CC(C5)C3.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Neuroscience
Electroacupuncture reduces microglial pyroptosis via P2X7R/NLRP3 axis in the rat model of asphyxial cardiac arrest and cardiopulmonary resuscitation. [Abstract]2025 Mar 27:570:27-37. PMID: 39952315 -
Int J Med Microbiol
Chlamydia psittaci inhibits apoptosis of human neutrophils by activating P2X7 receptor expression. [Abstract]2022 Dec;312(8):151571. PMID: 36511277
Solvent & Solubility
DMSO : 8.33 mg/mL (16.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2 mg/mL (4.04 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Allsopp RC, et al. Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120. Sci Rep. 2017 Apr 7;7(1):725. [Content Brief]
[2]. Kan LK, et al. P2X7 receptor antagonism by AZ10606120 significantly reduced in vitro tumour growth in human glioblastoma. Sci Rep. 2023 May 24;13(1):8435. [Content Brief]
[3]. Giannuzzo A, et al. The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells. Mol Cancer. 2015 Nov 25;14:203. [Content Brief]
[4]. Clapp C, et al. Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes. Acta Diabetol. 2019 Sep;56(9):1031-1036. [Content Brief]
[5]. Csölle C, et al. Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. PLoS One. 2013 Jun 21;8(6):e66547. [Content Brief]
[6]. Pegoraro A, et al. Differential sensitivity of acute myeloid leukemia cells to daunorubicin depends on P2X7A versus P2X7B receptor expression. Cell Death Dis. 2020 Oct 18;11(10):876. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.0182 mL | 10.0912 mL | 20.1824 mL | 50.4561 mL |
| DMSO | 5 mM | 0.4036 mL | 2.0182 mL | 4.0365 mL | 10.0912 mL |
| 10 mM | 0.2018 mL | 1.0091 mL | 2.0182 mL | 5.0456 mL | |
| 15 mM | 0.1345 mL | 0.6727 mL | 1.3455 mL | 3.3637 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
AZ10606120 dihydrochloride Related Classifications
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