1. Membrane Transporter/Ion Channel
    Autophagy
  2. P2X Receptor
    Autophagy
  3. A-317491

A-317491 

Cat. No.: HY-15568 Purity: 99.18%
Handling Instructions

A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.

For research use only. We do not sell to patients.

A-317491 Chemical Structure

A-317491 Chemical Structure

CAS No. : 475205-49-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 152 In-stock
Estimated Time of Arrival: December 31
5 mg USD 122 In-stock
Estimated Time of Arrival: December 31
10 mg USD 182 In-stock
Estimated Time of Arrival: December 31
50 mg USD 617 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of A-317491:

Top Publications Citing Use of Products

    A-317491 purchased from MCE. Usage Cited in: Int J Nanomedicine. 2017 Nov 9;12:8171-8183.

    PC12 cell fluorescence images of baseline (before ATP stimulation), 0 s (the brightest fluorescence images after ATP stimulation), 50 s, 100 s, 150 s, and 200 s. Ca2+ peak increase (∆F/F0) in PC12 cells incubated with A-317491 salt, CSOSA/NLC, and CSOSA/NLC/A-317491 for predetermined time under 100 μM ATP stimulation.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. IC50 value: Target: P2X2/3 It is known that P2X3 and P2X2/3 receptors stimulate the pronociceptive effects of ATP upon activation. Studies indicate that the P2X3 receptor is implicated in both neuropathic and inflammatory pain. P2X3 receptor is a promising target for therapeutic intervention in cancer patients for pain management.

    Molecular Weight

    565.57

    Formula

    C₃₃H₂₇NO₈

    CAS No.

    475205-49-3

    SMILES

    O=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[[email protected]]4CCCC5=C4C=CC=C5)=O)=C(C(O)=O)C=C1C(O)=O)O

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 47 mg/mL (83.10 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7681 mL 8.8406 mL 17.6813 mL
    5 mM 0.3536 mL 1.7681 mL 3.5363 mL
    10 mM 0.1768 mL 0.8841 mL 1.7681 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.42 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (4.42 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.42 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.18%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    A-317491
    Cat. No.:
    HY-15568
    Quantity: