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  3. A-317491 sodium salt hydrate

A-317491 sodium salt hydrate 

Cat. No.: HY-15568A Purity: 99.65%
Handling Instructions

A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.

For research use only. We do not sell to patients.

A-317491 sodium salt hydrate Chemical Structure

A-317491 sodium salt hydrate Chemical Structure

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 163 In-stock
Estimated Time of Arrival: December 31
5 mg USD 122 In-stock
Estimated Time of Arrival: December 31
10 mg USD 182 In-stock
Estimated Time of Arrival: December 31
50 mg USD 617 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of A-317491 sodium salt hydrate:

Top Publications Citing Use of Products

    A-317491 sodium salt hydrate purchased from MCE. Usage Cited in: Int J Nanomedicine. 2017 Nov 9;12:8171-8183.

    PC12 cell fluorescence images of baseline (before ATP stimulation), 0 s (the brightest fluorescence images after ATP stimulation), 50 s, 100 s, 150 s, and 200 s. Ca2+ peak increase (∆F/F0) in PC12 cells incubated with A-317491 salt, CSOSA/NLC, and CSOSA/NLC/A-317491 for predetermined time under 100 μM ATP stimulation.
    • Biological Activity

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    • References

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    Description

    A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. IC50 value: Target: P2X2/3 receptor It is known that P2X3 and P2X2/3 receptors stimulate the pronociceptive effects of ATP upon activation. Studies indicate that the P2X3 receptor is implicated in both neuropathic and inflammatory pain. P2X3 receptor is a promising target for therapeutic intervention in cancer patients for pain management.

    Molecular Weight

    606.57

    Formula

    C₃₃H₂₉NNaO₉

    SMILES

    O=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[[email protected]]4CCCC5=C4C=CC=C5)=O)=C(C(O)=O)C=C1C(O)=O)O.[Na].O

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 100 mg/mL (164.86 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6486 mL 8.2431 mL 16.4861 mL
    5 mM 0.3297 mL 1.6486 mL 3.2972 mL
    10 mM 0.1649 mL 0.8243 mL 1.6486 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.65%

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    Product Name:
    A-317491 sodium salt hydrate
    Cat. No.:
    HY-15568A
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