1. Saccharides and Glycosides
  2. Timosaponin BII

Timosaponin BII (Synonyms: Prototimosaponin A III)

Cat. No.: HY-N0812 Purity: 98.63%
Handling Instructions

Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities.

For research use only. We do not sell to patients.

Timosaponin BII Chemical Structure

Timosaponin BII Chemical Structure

CAS No. : 136656-07-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 162 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 162 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities[1][2].

In Vitro

Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

921.07

Formula

C₄₅H₇₆O₁₉

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (108.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0857 mL 5.4285 mL 10.8569 mL
5 mM 0.2171 mL 1.0857 mL 2.1714 mL
10 mM 0.1086 mL 0.5428 mL 1.0857 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.71 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥99.0%

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Keywords:

Timosaponin BIIPrototimosaponin A IIIOthersoxidativestressdementia-palliativeAlzheimer'sdiseaseADInhibitorinhibitorinhibit

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Product Name:
Timosaponin BII
Cat. No.:
HY-N0812
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