1. Saccharides and Glycosides

Timosaponin BII (Synonyms: Prototimosaponin A III)

Cat. No.: HY-N0812 Purity: 98.52%
Handling Instructions

Timosaponin BII is an antioxidant and an anti-inflammatory agent.

For research use only. We do not sell to patients.

Timosaponin BII Chemical Structure

Timosaponin BII Chemical Structure

CAS No. : 136656-07-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 122 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Timosaponin BII is an antioxidant and an anti-inflammatory agent.

In Vitro

Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells[1].

In Vivo

Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0857 mL 5.4285 mL 10.8569 mL
5 mM 0.2171 mL 1.0857 mL 2.1714 mL
10 mM 0.1086 mL 0.5428 mL 1.0857 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

921.07

Formula

C₄₅H₇₆O₁₉

CAS No.

136656-07-0

SMILES

C[[email protected]@]1([[email protected]]([[email protected]@H]2C)([H])[[email protected]](O[[email protected]]2(O)CC[[email protected]](C)CO[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]3O)O)O[[email protected]@H]3CO)([H])C4)[[email protected]]4([H])[[email protected]@](CC[[email protected]@]5([H])[[email protected]@]6(CC[[email protected]](O[[email protected]@](O[[email protected]](CO)[[email protected]](O)[[email protected]@H]7O)([H])[[email protected]@H]7O[[email protected]]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]8O)O)([H])O[[email protected]@H]8CO)C5)C)([H])[[email protected]]6([H])CC1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Timosaponin BII
Cat. No.:
HY-N0812
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Timosaponin BII

Cat. No.: HY-N0812