1. Saccharides and Glycosides
  2. Timosaponin BII

Timosaponin BII (Synonyms: Prototimosaponin A III)

Cat. No.: HY-N0812 Purity: 98.52%
Handling Instructions

Timosaponin BII is an antioxidant and an anti-inflammatory agent.

For research use only. We do not sell to patients.

Timosaponin BII Chemical Structure

Timosaponin BII Chemical Structure

CAS No. : 136656-07-0

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Timosaponin BII is an antioxidant and an anti-inflammatory agent.

In Vitro

Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells[1].

In Vivo

Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2].

Molecular Weight

921.07

Formula

C₄₅H₇₆O₁₉

CAS No.

136656-07-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Timosaponin BII
Cat. No.:
HY-N0812
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