Monogalactosyldiacylglycerol
Monogalactosyldiacylglycerol (MGDG) is a galactolipid with anti-inflammatory and anticancer activities, which is found in photosynthetic organisms. Monogalactosyldiacylglycerol is a potent DNA polymerase inhibitor with pro-apoptotic activity. Monogalactosyldiacylglycerol inhibits the synthesis of LPS (HY-D1056)-induced inflammation-related proteins (Ex-FABP, Avidin, Serum Amyloid A). Monogalactosyldiacylglycerol exerts an anti-proliferative effect on chicken articular chondrocytes. Monogalactosyldiacylglycerol can be used in research related to osteoarthritis, cancer and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 1932659-76-1
- Formula: C45H74O10
- Molecular Weight:775.06
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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DNA Polymerase |
Monogalactosyldiacylglycerol (10-100 μM; overnight) dose-dependently inhibits the expression of inflammation-related proteins Ex-FABP, Avidin and SAA in LPS-stimulated adult avian articular chondrocytes[1].
Monogalactosyldiacylglycerol (50 μM; 0-7 days) impairs the proliferative capacity of articular chondrocytes in adult avians, but does not reduce cell viability over a 7-day culture period[1].
Monogalactosyldiacylglycerol (50 μM; overnight) does not induce phenotypic changes in adult avian articular chondrocytes, nor does it impair their differentiation or redifferentiation capacity; this is supported by unchanged expression of the SOX9 and type II collagen markers[1].
Monogalactosyldiacylglycerol exhibits anti-inflammatory activity in LPS-stimulated RAW264.7 macrophages[2].
Monogalactosyldiacylglycerol exhibits proapoptotic activity in immortalized mouse epithelial W2 cells[2].
Monogalactosyldiacylglycerol exhibits DNA polymerase inhibitory activity and enhances the chemotherapy efficacy of human pancreatic cancer cell lines[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:adult avian articular chondrocytes
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Concentration:50 μM
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Incubation Time:0, 3, 5, 7 days
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Result:Did not affect cell viability (all cells stained positive for MTT).
Reduced the number of cells significantly compared to controls across 7 days of culture.
Monogalactosyldiacylglycerol exerts potent, dose-dependent anti-inflammatory activity in the mouse carrageenan (HY-125474)-induced paw edema model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1932659-76-1
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Appearance Solid
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Molecular Weight 775.06
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Formula C45H74O10
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Color White to yellow
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SMILES
CC/C=C\C/C=C\C/C=C\CCCCCCCC(OC[C@@H](O)CO[C@@H]1O[C@@H]([C@@H]([C@@H]([C@H]1O)O)O)COC(CCCCCCC/C=C\C/C=C\C/C=C\CC)=O)=O
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Synonyms
MGDG
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1].
Lenti M, et al. Monogalactosyldiacylglycerol anti-inflammatory activity on adult articular cartilage. Nat Prod Res. 2009;23(8):754-62.
[Content Brief]
[2]. Riccio G, et al. Monogalactosyldiacylglycerol and Sulfolipid Synthesis in Microalgae. Mar Drugs. 2020;18(5):237. Published 2020 May 1. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Monogalactosyldiacylglycerol Related Classifications
HY-N12540 Related Classifications
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