1. Apoptosis
  2. Apoptosis
  3. Methylophiopogonanone A

Methylophiopogonanone A 

Cat. No.: HY-N2437
Handling Instructions

Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties.

For research use only. We do not sell to patients.

Methylophiopogonanone A Chemical Structure

Methylophiopogonanone A Chemical Structure

CAS No. : 74805-92-8

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Description

Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties[1].

In Vitro

Methylophiopogonanone A (MO-A; 10 μmol/L) significantly decreases apoptosis and cleaved caspase-3 expression, elevated the Bcl-2/Bax ratio and restored NO production. Pretreatment with Methylophiopogonanone A (MO-A) markedly increases the activation of PI3K/Akt/eNOS pathway in H9C2 cells subjected to H/R, and the protective effects of MO-A are abolished in the presence of the PI3K inhibitor wortmannin (100 nmol/L)[1].

In Vivo

Methylophiopogonanone A (MO-A;10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury[1].

Molecular Weight

342.34

Formula

C₁₉H₁₈O₆

CAS No.

74805-92-8

SMILES

O=C1[[email protected]](CC2=CC=C(OCO3)C3=C2)COC4=C(C)C(O)=C(C)C(O)=C14

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Methylophiopogonanone AApoptosisInhibitorinhibitorinhibit

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