Cat. No.: HY-N2082

Isorhamnetin 3-O-galactoside

(Synonyms: Cacticin)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases.

For research use only. We do not sell to patients.

Purity: 99.64%
CAS No.: 6743-92-6
Formula: C₂₂H₂₂O₁₂
Molecular Weight:478.40

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Isorhamnetin 3-O-galactoside Chemical Structure

CAS No.: 6743-92-6

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All COX Isoforms :

All ERK Isoforms :

All JNK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BMDC	IC₅₀	>50 μM Compound: 11	Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA	[PMID: 25769817]
BMDC	IC₅₀	>50 μM Compound: 11	Inhibition of LPS-induced IL-6 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA Inhibition of LPS-induced IL-6 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA	[PMID: 25769817]
BMDC	IC₅₀	>50 μM Compound: 11	Inhibition of LPS-induced TNF-alpha production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA Inhibition of LPS-induced TNF-alpha production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA	[PMID: 25769817]
C2C12	EC₅₀	18.5 μM Compound: 6	Increase in glucose uptake in mouse C2C12 cells incubated for 18 hrs using [3H]-2-deoxy-D-glucose by liquid scintillation counting Increase in glucose uptake in mouse C2C12 cells incubated for 18 hrs using [3H]-2-deoxy-D-glucose by liquid scintillation counting	[PMID: 22738356]
Monocyte	IC₅₀	3.8 μM Compound: isorhamnetin 3-glucoside	Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs	[PMID: 8882428]

In Vitro

Isorhamnetin 3-O-galactoside (0.5-50 μM) inhibits TNF-α/FVIIa-mediated thrombin and FXa production in HUVECs^[2].
Isorhamnetin 3-O-galactoside (0.5-50 μM, 18 h) dose-dependently inhibits TNF-α-induced PAI-1 secretion in HUVECs^[2].
Isorhamnetin 3-O-galactoside (1-5 μM, 6 h) potently inhibits LPS (100 ng/ml, 16 h)-induced HMGB1 release in HUVECs^[3].
Isorhamnetin 3-O-galactoside (1-5 μM, 6 h) decreases LPS- or HMGB1-induced barrier disruption ^[3].
Isorhamnetin 3-O-galactoside (5 μM, 6 h) inhibits HMGB1-induced paracellular gap formation in HUVECs and promotes the formation of dense F-actin rings, maintaining the morphological integrity of endothelial cells^[3].
Isorhamnetin 3-O-galactoside (1-5 μM, 6 h) suppresses HMGB1-induced expression of vascular cell adhesion molecule-1 (VCAM-1) in HUVECs^[3].
Isorhamnetin-3-O-galactoside (1-5 μM, 6 h) significantly suppresses HMGB1-induced activation of Phospho-NF-κB p65 and TNF-α in HUVEC nuclear lysates^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Isorhamnetin 3-O-galactoside (50-200 mg/kg, i.p., twice: 30 min before and 2 h after CCl4 injection) attenuates CCl4-induced hepatic injury in male ICR mice^[1].
Isorhamnetin 3-O-galactoside (2.4 mg/kg, intravenous administration, once) significantly prolongs the tail bleeding time^[2].
Isorhamnetin 3-O-galactoside (4.8 mg/mouse, i.v., once) markedly inhibits HMGB1 release in cecal ligation and puncture (CLP)-induced septic male C57BL/6 mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male ICR mice (25-30 g) were intraperitoneally injected with CCl4^[1]
Dosage:

50, 100, 200 mg/kg
Administration:

i.p., twice: 30 min before and 2 h after CCl4 injection
Result:

Attenuated ALT and AST activities.
Reduced MDA and TNF-α levels.
Inhibited CCl4-induced upregulation of hepatic iNOS and COX-2 protein and mRNA expression, and enhanced CCl4-induced increase in hepatic HO-1 protein and mRNA expression.
Reduced the expression of JNK, ERK, and NF-κB.

Chemical Information

CAS No. 6743-92-6
Appearance Solid
Molecular Weight 478.40
Formula C₂₂H₂₂O₁₂
Color White to yellow
SMILES

O=C1C(O[C@H]2[C@@H]([C@H]([C@H]([C@@H](CO)O2)O)O)O)=C(C3=CC=C(O)C(OC)=C3)OC4=CC(O)=CC(O)=C14
Synonyms

Cacticin
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

All

Sort by:

Journal Impact Factor

Research Square Print

2022 May.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (209.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0903 mL

10.4515 mL

20.9030 mL

5 mM

0.4181 mL

2.0903 mL

4.1806 mL

10 mM

0.2090 mL

1.0452 mL

2.0903 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim DW, et al. Isorhamnetin-3-O-galactoside Protects against CCl4-Induced Hepatic Injury in Mice. Biomol Ther (Seoul). 2012 Jul;20(4):406-12. [Content Brief]

[2]. Ku SK, et al. Antithrombotic and profibrinolytic activities of isorhamnetin-3-O-galactoside and hyperoside. Food Chem Toxicol. 2013 Mar;53:197-204. [Content Brief]

[3]. Kim TH, et al. Anti-inflammatory activities of isorhamnetin-3-O-galactoside against HMGB1-induced inflammatory responses in both HUVECs and CLP-induced septic mice. J Cell Biochem. 2013 Feb;114(2):336-45. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0903 mL	10.4515 mL	20.9030 mL	52.2575 mL
	5 mM	0.4181 mL	2.0903 mL	4.1806 mL	10.4515 mL
	10 mM	0.2090 mL	1.0452 mL	2.0903 mL	5.2258 mL
	15 mM	0.1394 mL	0.6968 mL	1.3935 mL	3.4838 mL
	20 mM	0.1045 mL	0.5226 mL	1.0452 mL	2.6129 mL
	25 mM	0.0836 mL	0.4181 mL	0.8361 mL	2.0903 mL
	30 mM	0.0697 mL	0.3484 mL	0.6968 mL	1.7419 mL
	40 mM	0.0523 mL	0.2613 mL	0.5226 mL	1.3064 mL
	50 mM	0.0418 mL	0.2090 mL	0.4181 mL	1.0452 mL
	60 mM	0.0348 mL	0.1742 mL	0.3484 mL	0.8710 mL
	80 mM	0.0261 mL	0.1306 mL	0.2613 mL	0.6532 mL
	100 mM	0.0209 mL	0.1045 mL	0.2090 mL	0.5226 mL

Keywords

Isorhamnetin 3-O-galactoside

1 Cited Publications

100 mg Get Quote

Subscribe to the

MedChemExpress

Newsletter

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Isorhamnetin 3-O-galactoside

Bioactive Compound Library Max

Bioactive Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Metabolism/Protease Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Aging Compound Library

Reprogramming Compound Library

Glycoside Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Medicine Food Homology Compound Library

Phenols Library

Glutamine Metabolism Compound Library

Traditional Chinese Medicine Active Compound Library

Flavonoids Library

Anti-Parkinson's Disease Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Food-Sourced Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Antidepressant Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Coagulation and Anti-coagulation Compound Library

Heterocyclic Compound Library

Pain-Related Compound Library

Metabolic Enzyme Compound Library

Protease Inhibitor Library

Serine/Threonine Kinase Inhibitor Library

Multi-Target Compound Library

Radioprotector Library

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Tibetan Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Anti-Rheumatic Arthritis Compound Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Isorhamnetin 3-O-galactoside

All COX Isoforms

All ERK Isoforms

All JNK Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Isorhamnetin 3-O-galactoside Related Classifications

HY-N2082 Related Classifications