Ability of different flavonoids to inhibit the procoagulant activity of adherent human monocytes

  • J Nat Prod. 1996 Mar;59(3):273-6. doi: 10.1021/np960057s.
A Lale  1 ,  J M Herbert ,  J M Augereau ,  M Billon ,  M Leconte ,  J Gleye
Affiliations
  • 1. Sanofi Recherche, Toulouse, France.
PMID: 8882428 DOI: 10.1021/np960057s
Abstract

Sixty-five natural Flavonoids of various chemical classes were screened for their ability to inhibit the procoagulant activity of adherent human monocytes stimulated by endotoxin and interleukin-1 beta in vitro. Eighteen of these compounds inhibited the interleukin-1 beta-induced expression of tissue factor on human monocytes, but the most active compound was a biflavonoid: hinokiflavone.