Thioflosulide
Thioflosulide (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC50 of 2.3 nM, and shows anti-inflammatory activity.
For research use only. We do not sell to patients.
- CAS No.: 158205-05-1
- Formula: C16H13F2NO3S2
- Molecular Weight:369.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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COX-2 2.3 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.029 μM
Compound: L-745337
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Inhibition of human Prostaglandin G/H synthase 2 expressed in CHO (chinese hamster ovary) cells
Inhibition of human Prostaglandin G/H synthase 2 expressed in CHO (chinese hamster ovary) cells
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[PMID: 10021918] |
| U-937 | IC50 |
>50 μM
Compound: 20
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Inhibition of Prostaglandin G/H synthase 1 in human U937 cells
Inhibition of Prostaglandin G/H synthase 1 in human U937 cells
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[PMID: 8523403] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 158205-05-1
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Molecular Weight 369.41
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Formula C16H13F2NO3S2
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SMILES
CS(=O)(NC1=CC2=C(C(CC2)=O)C=C1SC3=CC=C(F)C=C3F)=O
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Synonyms
L-745337
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kroin JS, et al. Cyclooxygenase-2 inhibition potentiates morphine antinociception at the spinal level in a postoperative pain model. Reg Anesth Pain Med. 2002 Sep-Oct;27(5):451-5. [Content Brief]
[2]. Turull N, et al. Effect of the COX-2 selective inhibitor l-745,337 on inflammation and organ prostaglandin E2 (PGE2) levels in adjuvant arthritic rats. Inflammation. 2000 Dec;24(6):533-45. [Content Brief]
[3]. Li CS, et al. Cyclooxygenase-2 inhibitors. Synthesis and pharmacological activities of 5-methanesulfonamido-1-indanone derivatives. J Med Chem. 1995 Dec 8;38(25):4897-905. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thioflosulide Related Classifications
HY-19217 Related Classifications
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