1. Immunology/Inflammation
  2. COX
  3. Thioflosulide

Thioflosulide (Synonyms: L-745337)

Cat. No.: HY-19217
Handling Instructions

Thioflosulide (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC50 of 2.3 nM, and shows anti-inflammatory activity.

For research use only. We do not sell to patients.

Thioflosulide Chemical Structure

Thioflosulide Chemical Structure

CAS No. : 158205-05-1

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Description

Thioflosulide (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC50 of 2.3 nM, and shows anti-inflammatory activity.

IC50 & Target[3]

COX-2

2.3 nM (IC50)

In Vivo

In a rat model of postoperative pain, Thioflosulide (L-745337) (40-80 μg, intrathecal) coadministered with intrathecal morphine (0.5 nmol) increases the withdrawal thresholds in a dose-dependent manner. Adding 80 μg Thioflosulide (L-745337) to 1 nmol morphine produces an antiallodynic effect greater than that of morphine at twice the dose. Thioflosulide (L-745337) (0-30 mg/kg, s.c.) combined with intrathecal morphine results in the same antiallodynic response as morphine alone[1]. Thioflosulide (L-745337) shows anti-inflammatory activity, with the effective-dose of 0.4 mg/kg, and the maximal anti-inflammation dose of 5 mg/kg in arthritic rats[2].

Molecular Weight

369.41

Formula

C₁₆H₁₃F₂NO₃S₂

CAS No.

158205-05-1

SMILES

CS(=O)(NC1=CC2=C(C(CC2)=O)C=C1SC3=CC=C(F)C=C3F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ThioflosulideL-745337L745337L 745337COXCyclooxygenaseInhibitorinhibitorinhibit

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