1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR
  3. RPT193

RPT193 

Cat. No.: HY-148074
Handling Instructions

RPT193 is an orally active inhibitor of CCR4, blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. RPT193 can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research.

For research use only. We do not sell to patients.

RPT193 Chemical Structure

RPT193 Chemical Structure

CAS No. : 2366152-15-8

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Description

RPT193 is an orally active inhibitor of CCR4, blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. RPT193 can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research[1].

IC50 & Target

CCR4

 

In Vitro

RPT193 (1 nM-10 μM) inhibits Th2 cells chemotaxis or migration with IC50s of ~370 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RPT193 (100 mg/kg; p.o.; once daily; 2 d, 1 d before OVA-challenge) reduces skin inflammation in an acute ovalbumin (OVA)-induced atopic dermatitis model in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute ovalbumin (OVA)-induced atopic dermatitis model in mouse[2]
Dosage: 100 mg/kg
Administration: Oral gavage; once daily; for 2 days, started 1 day before OVA-challenge (in mouse ear)
Result: Decreased the ear thickness significantly.
Molecular Weight

566.95

Formula

C27H34Cl3N5O2

CAS No.
SMILES

C[[email protected]](C1=C(C=C(C=C1)Cl)Cl)NC2=NC(N3CC([[email protected]@H]4CN([[email protected]]5C[[email protected]@](C)(C5)C(O)=O)CCC4)C3)=NC(C)=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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RPT193
Cat. No.:
HY-148074
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