2. Anti-infection Immunology/Inflammation
  3. Bacterial CD28
  4. Reltecimod

Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Reltecimod Chemical Structure

Reltecimod Chemical Structure

CAS No. : 1447799-33-8

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Description

Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs)[1][2].

IC50 & Target

TP44, Bacteria[1][2]
In Vivo

Reltecimod (1.25-5 mg/kg; i.v.) increases the survival rate of mice infected with different bacteria[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogen-free, female BALB/c mice (Acute bacterial peritonitis was induced by i.p. administration with E. coli 018:K1)[2]
Dosage: 1.25 or 5 mg/kg
Administration: i.v.; single dosage; at 4 h post infection
Result: Resulted in 100% survival at single dosage of 5 mg/kg, at day 6.
Resulted in 70% survival at 4 dosage (at 1, 12, 24 and 36 h post infection) of 1.25 mg/kg, at day 6.
Animal Model: Pathogen-free, female BALB/c mice (NSTI induced by thigh i.m. administration with Streptococcus pyogenes)[2]
Dosage: 2.5 or 5 mg/kg
Administration: i.v.; single dosage; at 1 h, or at 1 h and 12 or 72 h post infection
Result: Resulted in 65% survival at single dosage of 2.5 mg/kg, at day 8.
Resulted in 30% survival at two dosage (1 and 12 h post infection) of 2.5 mg/kg, at day 8.
Resulted in 90% survival at single dosage (1 h post infection) of 5 mg/kg, at day 6.
Animal Model: Pathogen-free, female BALB/c mice [Cecal ligation and puncture (CLP) model][2]
Dosage: 1.25, 2.5, or 5 mg/kg
Administration: i.v.; single dosage
Result: Increased day 7 survival by up to 100%.
Clinical Trial
Molecular Weight

1037.19

Formula

C46H72N10O15S
CAS No.
Sequence Shortening

ASPMLVAYDA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Reltecimod Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Reltecimod1447799-33-8AB-103AB103AB 103BacterialCD28NSTIsTP44T cellE. coliStreptococcus pyogenesCecal ligation and punctureCLPInhibitorinhibitorinhibit

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