1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
    Immunology/Inflammation
  2. Dihydroorotate Dehydrogenase
    DNA/RNA Synthesis
    Interleukin Related
  3. Vidofludimus

Vidofludimus (Synonyms: 4sc-101; SC12267)

Cat. No.: HY-14908 Purity: 99.14%
Handling Instructions

Vidofludimus(4SC-101; SC12267) is a novel immunosuppressive drug that inhibits DHODH; inhibits IL-17 secretion in vitro independently of effects on lymphocyte proliferation.

For research use only. We do not sell to patients.

Vidofludimus Chemical Structure

Vidofludimus Chemical Structure

CAS No. : 717824-30-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 640 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Vidofludimus(4SC-101; SC12267) is a novel immunosuppressive drug that inhibits DHODH; inhibits IL-17 secretion in vitro independently of effects on lymphocyte proliferation. IC50 value: Target: DHODH inhibitor in vitro: 4SC-101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin-stimulated IL-17 production by lymphocytes [2]. in vivo: In vivo Vido treatment alone most effectively reduced macroscopic and histological pathology and the numbers of CD3+ T cells. In contrast, similarly reduced nuclear signal transducer and activator of transcription 3 (STAT3) binding and IL-17 levels were observed from animals treated with Vido alone and Vido + Uri. Vido improves TNBS-induced colonic inflammation by a unique dual mode of action [1]. Oral administration of 4SC-101 effectively improved both chronic DSS and acute TNBS colitis in mice. In these colitis models the overall efficacy profile of 4SC-101 was similar to that of dexamethasone [2].

IC50 & Target

IL-17

 

Clinical Trial
Molecular Weight

355.36

Formula

C₂₀H₁₈FNO₄

CAS No.

717824-30-1

SMILES

O=C(C1=C(C(NC2=CC=C(C3=CC=CC(OC)=C3)C=C2F)=O)CCC1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 46 mg/mL (129.45 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8140 mL 14.0702 mL 28.1405 mL
5 mM 0.5628 mL 2.8140 mL 5.6281 mL
10 mM 0.2814 mL 1.4070 mL 2.8140 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (7.04 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.04 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.04 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.14%

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Keywords:

Vidofludimus4sc-101 SC12267SC12267SC 12267SC-12267Dihydroorotate DehydrogenaseDNA/RNA SynthesisInterleukin RelatedDHODHILInhibitorinhibitorinhibit

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Product Name:
Vidofludimus
Cat. No.:
HY-14908
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